Synthesis Of Novel Heterocyclic Quinolone Compound For Anti -tubercular Activity

Simple item page
dc.contributor.authorGodge, Rahul K.en_US
dc.contributor.authorKunkulol, Rahulen_US
dc.date.accessioned2020-05-05T07:06:12Z
dc.date.available2020-05-05T07:06:12Z
dc.date.issued2018-07
dc.description.abstractIn last few decades, though significant progress has been made in the treatment and control strategies of tubercular infections by introducing new diagnostic and monitoring tools and combination therapy, it still continues to be se-vere problem. The need of study was only because of there are many drugs in market to treat infection but most of the drugs are showing resistance because of the same it is difficult to treat the infection. In this study we chosen quinolone nucleus for study and over it. Thus with the aim of developing novel molecule with improved potency for treating Mycobacterium tuberculosisH37Rv strain infections and with decreased probability of developing drug re-sistance. Methodology:The synthesis of Quinolone derivatives, starting from substituted aniline and ethyl acetoace-tate, by conventional organic reaction and results of investigations of their anti-mycobacterial activity.Results: MICs of the synthesized compounds are compared with existing drugs Cytotoxicity. The substituted quinolones are synthe-sized by taking mixture of7-substituted-2-(3-chloro-2-oxopropyl) quinolin-4(1H)-one and different secondary amines. Many compounds have shown promising activity while some were inactive. Conclusion:It was found that Compound A1,A3,B1,B3,have shown promising anti tubercular activity whereas compound A2, A4,B2,B4were showing moderate anti tubercular activity against std. Streptomycin.en_US
dc.identifier.affiliationsPravara Rural College of Pharmacy, Loni BK Rahata, Ahmednagar, 413736 (M.S.). Indiaen_US
dc.identifier.affiliationsPravara Institute of Medical Sciences, Loni BK Rahata, Ahmednagar, 413736 (M.S.). Indiaen_US
dc.identifier.citationGodge Rahul K., Kunkulol Rahul. Synthesis Of Novel Heterocyclic Quinolone Compound For Anti -tubercular Activity. International Journal of Clinical and Biomedical Research. 2018 Jul; 4(3): 44-49en_US
dc.identifier.issn2395-0471
dc.identifier.issn2521-0394
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200820
dc.languageenen_US
dc.publisherSumathi Publicationsen_US
dc.relation.issuenumber3en_US
dc.relation.volume4en_US
dc.source.urihttps://www.doi.org/10.31878/ijcbr.2018.43.10en_US
dc.subjectQuinolone derivativeen_US
dc.subjectWell diffusion methoden_US
dc.subjectSpectral analysisen_US
dc.subjectElemental analysis.en_US
dc.titleSynthesis Of Novel Heterocyclic Quinolone Compound For Anti -tubercular Activityen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijcbr2018v4n3p44.pdf
Size:
299.55 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Clinical and Biomedical Research (IJCBR)