EXPRESSION OF CD44 AS A CANCER STEM CELL MARKER IN ORAL CANCER: A META-ANALYSIS STUDY
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Date
2022-06
Journal Title
Journal ISSN
Volume Title
Publisher
Era's Lucknow Medical College & Hospital, Lucknow
Abstract
Various researches have shown that Cluster of Differentiation 44 (CD44) is one of the valued markers. As it plays an important role in tumor growth and metastasis but studies also suggest it as a cancer stem cell (CSC) marker in oral cancer (OC). Therefore, we aimed to explore association between the expression of CD44 and clinicopathological characteristics along with the OC prognosis.We conducted literature search through PubMed database (till October 22, 2020) to determine and evaluate the clinical and prognostic significance of CD44 expression in OC patients. According to the inclusion criteria we finalized 9 studies with 867 OC cases. We found the positive expression of CD44 in advanced stages was prominently associated with reduced survival rate. Our analysis suggest that higher tumor expression of CD44 may predict poor survival in end staged OC patient
Description
Keywords
Cancer Stem Cells, CD44, Oral Cancer, Tumor grade, Prognosis
Citation
Sohail M, Charles M. R, Ahamad E, Gulfsha Sahu D, Siddiqui Z.. EXPRESSION OF CD44 AS A CANCER STEM CELL MARKER IN ORAL CANCER: A META-ANALYSIS STUDY. Era's Journal of Medical Research. 2022 Jun; 9(1): 52-59