Immunopathogenesis and Treatment of Rheumatoid Arthritis: Recent Developments.

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dc.contributor.authorGiasuddin, A S M
dc.contributor.authorJhuma, K A
dc.contributor.authorHaq, A M M
dc.contributor.authorHaque, M M
dc.date.accessioned2015-12-07T03:38:54Z
dc.date.available2015-12-07T03:38:54Z
dc.date.issued2014
dc.description.abstractRheumatoid arthritis (RA) is a chronic inflammatory disease occurring three times more in females throughout the world affecting 1-2% of the adult population in all ethnic groups, usually in the age group of 25-60 years. Although the role of CD4 + T helper lymphocytes in the aetiopathogenesis has been studied for more than three decades, the focus on CD4 + T helper type 17 (Th17) lymphocytes and its associated cytokines is much more recent. The cytokines such as IL-17 and IFN-g induce secondary cytokines such as IL-1, TNF-a , etc which possibly cause inflammation in joints. This cytokine cascade, therefore, offers a number of points and opportunities for immunointervention in RA. The present review article highlights some of the major aspects of the immunopathogenesis that involve Th17 cells and their association relevant to recent developments in the treatment of RA.en_US
dc.identifier.citationGiasuddin A S M, Jhuma K A, Haq A M M , Haque M M. Immunopathogenesis and Treatment of Rheumatoid Arthritis: Recent Developments. Bangladesh Journal of Medical Biochemistry. 2014; 7(2): 62-67.en_US
dc.identifier.issn2073-9915
dc.identifier.issn2408-8331
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/167263
dc.language.isoenen_US
dc.source.urihttps://banglajol.info/index.php/BJMB/article/view/22415en_US
dc.subjectRheumatoid arthritisen_US
dc.subjectImmunopathogenesisen_US
dc.subjectCytokinesen_US
dc.subjectInterlenkin-17en_US
dc.subjectCD4 +Th17 cellen_US
dc.titleImmunopathogenesis and Treatment of Rheumatoid Arthritis: Recent Developments.en_US
dc.typeArticleen_US
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