Removal of radioactive strontium from the rat by feeding stable strontium.
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Date
1979-03
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Abstract
The effect of administering the stable isotope of strontium (as phosphate)
at different dietary levels to adult rats (fed on a cereal and pulse-based diet
containing 0·4% Ca) on the retention of radiostrontium (89Sr) and radiocalcium
(45Ca) in the femur and the whole skeleton was studied for a period up to 6 weeks
after an intraperitoneal injection of the two radioisotopes. The ability of strontium
to remove 89Sr under the above dietary conditions was examined. Feeding
Sr at 0·5% or 1% levels for 6 weeks had no effect on the skeletal content of 89Sr or
45Ca while a dietary regimen of 2% Sr (2000 times the normal content), significantly
lowered the 89Sr and 45Ca content by about 30% in the femur but not in the whole
skeleton. At this Sr level, the urinary excretion of the isotopes increased with a
concomitant decrease in their excretion in the faeces. This study underscores the
limitations of dietary Sr to mobilise 89Sr from the bones after it is incorporated in
the bone mineral.
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Keywords
89Sr removal, Sr feeding, rat, cereal and pulse diet
Citation
Kshirsagar S G. Removal of radioactive strontium from the rat by feeding stable strontium. Journal of Biosciences. 1979 Mar; 1(1): 99-107.