A Systematic Literature Review of Current Therapeutic Approaches for COVID-19 Patients
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Date
2020-05
Journal Title
Journal ISSN
Volume Title
Publisher
SCIENCEDOMAIN international
Abstract
Background:In December 2019, the pneumonia outbreak reported in Wuhan, Hubei Province, China. WHO introduced a novel coronavirus and the virus named Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) in January 2020. There are not any specific antiviral agents for coronavirus disease 19 (COVID‐19). Objective:Our review aimed to discuss treatment options and the efficacy of currently prescribed drugs and supportive care in COVID‐19 patients. Study Design:A literature review of the articles in the Web of Science, PubMed, Scopus and EMBASE conducted. Results: Lopinavir/ritonavir combination was the most frequently used drug, followed by Arbidol and Oseltamivir and Methylprednisolone. Lopinavir/Ritonavir outcome showed the fever and respiratory infection improve in day two and day eight, respectively. Also, negative PCR of SARS‐CoV‐2 in days six and 7day was seen and finally these patients discharged in 10 days. Conclusions: Lopinavir/Ritonavir was the most improving administrated antiviral combination, which might be a good option for COVID-19 due to its availability. Although supportive care such as O2supplementary and IV fluid therapy has improved outcomes. There are not evidence forsuggesting a new treatment or a new drug, which mean the necessity of further investigations for drug research in a clinical trial for a conclusion about the optimum treatment
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Keywords
Coronavirus, SARS virus, severe acute respiratory syndrome-related coronavirus 2, COVID-19, antiviral agents, drug therapy, therapeutics.
Citation
Soltani Saber, Zakeri Amir Mohammad, Karimi Mohammad Reza, Rezayat Sara Akhavan, Anbaji Fateme Zomorodi, Tabibzadeh Alireza, Yousefi Parastoo, Zakeri Armin, Jafarpour Ali, Norouzi Mehdi, Erfani Yousef, Poortahmasebi Vahdat. A Systematic Literature Review of Current Therapeutic Approaches for COVID-19 Patients. Journal of Pharmaceutical Research International. 2020 May; 32(7): 13-25