Antimicrobial Profile of Clinical Isolates in Intensive Car e Unit at a Tertiary Care Hospital

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dc.contributor.authorChidambaram, N.en_US
dc.contributor.authorRajan, Reenaen_US
dc.contributor.authorSasikala, G.en_US
dc.contributor.authorAnandi, V.en_US
dc.date.accessioned2020-09-24T07:52:03Z
dc.date.available2020-09-24T07:52:03Z
dc.date.issued2019-02
dc.description.abstractIntroduction: Intensive Care Units (ICU’s) provides a suitable environment for the proliferation and persistence of multidrug organisms. The burden of nosocomial infections among critically ill patients is much higher in developing countries. Aims and Objectives: The present study was conducted to know the prevalence of bacterial pathogens from various ICU’s of a tertiary care hospital and to determine their resistance profile. Materials and methods: A retrospective study was done on 188 isolates collected over a period of 10 months from January 2018 to October 2018. The isolates were identified by the conventional biochemical method and antimicrobial susceptibility testing was performed by Kirby bauer disc diffusion method. Results: The most common gram negative isolate obtained in this study was Klebsiella spp. About 90/188 (47.87%), followed by Pseudomonas aeruginosa 22/188 (11.70%), Acinetobacter spp. 21/188 (11.17%), and E. coli 20/188 (10.64%). The predominant gram positive cocci isolated were Enterococcus spp. 9/188 (4.79%). All gram negative bacilli were sensitive to Imipenem. About 23.33% of Klebsiella isolates were resistant to Piperacillin tazobactam and 18.89% to Cefoperazone sulbactam. The most effective drugs against gram negative bacilli were Imipenem, Piperacillin tazobactam, and Cefoperazone sulbactam. Conclusion: This study showed the prevalence of multidrug resistant Klebsiella spp. from various ICU’s. These isolates were resistant to third generation cephalosporins, quinolones, and aminoglycosides and were sensitive to carbapenems. Among the non-fermenting gram negative bacilli, the resistant rates were higher for Acinetobacter isolates compared to Pseudomonas aeruginosa.en_US
dc.identifier.affiliationsDepartment of Medicine, Rajah Muthiah Medical College, Annamalai University, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Surgery, Vinayaka Missions Medical College, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Penang International Dental College, Vinayaka Mission's Research Foundation (Deemed to be University), Salem, Indiaen_US
dc.identifier.affiliationsVIMS Hospital, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Vinayaka Mission’s Medical College, Tamil Nadu, Indiaen_US
dc.identifier.citationChidambaram N., Rajan Reena, Sasikala G., Anandi V.. Antimicrobial Profile of Clinical Isolates in Intensive Car e Unit at a Tertiary Care Hospital. International Journal of Medical Research & Health Sciences. 2019 Feb; 8(2): 160-166en_US
dc.identifier.issn2319-5886
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/204995
dc.languageenen_US
dc.publisherSumathi Publicationsen_US
dc.relation.issuenumber2en_US
dc.relation.volume8en_US
dc.source.urihttps://www.ijmrhs.com/abstract/antimicrobial-profile-of-clinical-isolates-in-intensive-car-e-unit-at-a-tertiary-care-hospital-15578.htmlen_US
dc.subjectIntensive care uniten_US
dc.subjectMultidrug resistanten_US
dc.subjectKlebsiellaen_US
dc.subjectThird generation cephalosporin resistanceen_US
dc.subjectCarbapenem sensitiveen_US
dc.titleAntimicrobial Profile of Clinical Isolates in Intensive Car e Unit at a Tertiary Care Hospitalen_US
dc.typeJournal Articleen_US
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