Adequacy of phosphodiesterase inhibitor in prevention and treatment of LPS induced organ failure in BALB/c mice

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dc.contributor.authorKhan, Ammaraen_US
dc.contributor.authorAfzal, Ayeshaen_US
dc.contributor.authorButt, Hammad A.en_US
dc.contributor.authorWaheed, Akbaren_US
dc.date.accessioned2020-04-23T07:54:50Z
dc.date.available2020-04-23T07:54:50Z
dc.date.issued2019-03
dc.description.abstractBackground: Even though with immense improvement and extensive understanding of pathophysiology of sepsis induced organ failure and affected population, it continues to put hundreds of people worldwide to eternal sleep due to lack of targeted therapy. Newer treatment modalities is the dire need of time. The present study was aimed to ascertain the adequacy of phosphodiesterases inhibitor - pentoxifylline (75mg/kg i.p) in endotoxin/LPS induced hepatotoxicity in BALB/c mice.Methods: The number of animals in each group was six. Endotoxin/lipopolysaccharides induced hepatotoxicity was reproduced in mice by giving lipopolysaccharide of serotype E. coli intraperitoneally. To ascertain the Preventive role, pentoxifylline was administered forehand LPS injection whereas therapeutic potential adjuged via post LPS delivering. The extent of liver damage was evaluated through serum alanine aminotransferases (ALT) and aspartate aminotransferase (AST) estimation along with histopathological examination of liver tissue.Results: Results set forth that serum ALT, AST levels and histological alteration abated considerably (p ?0.05) both in animals subjected to pentoxifylline pre and post-treatment.Conclusions: Pentoxifylline set up promising results in endotoxin induced hepatotoxicity and can be used therapeutic adjuncts to conventional treatment strategies in sepsis induced liver failure.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Therapeutics, Nawaz Sharif Medical College, University of Gujrat, Hafiz Hayat Campus, Gujrat, Pakistanen_US
dc.identifier.affiliationsDepartment of Pharmacology, Therapeutics, Wah Medical College, Wah Cantt, Wah, Pakistanen_US
dc.identifier.affiliationsDepartment of Pharmacology and Therapeutics, Combined Military Hospital Kharian, Pakistanen_US
dc.identifier.affiliationsDepartment of Pharmacology and Therapeutics, Islamic International Medical College, Riphah International University, Islamabad, Pakistanen_US
dc.identifier.citationKhan Ammara, Afzal Ayesha, Butt Hammad A., Waheed Akbar. Adequacy of phosphodiesterase inhibitor in prevention and treatment of LPS induced organ failure in BALB/c mice. International Journal of Basic & Clinical Pharmacology. 2019 Mar; 8(3): 549-556en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200063
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber3en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20190664en_US
dc.subjectEndotoxinen_US
dc.subjectGram negative sepsisen_US
dc.subjectHepatotoxicityen_US
dc.subjectLPSen_US
dc.subjectPentoxifyllineen_US
dc.subjectPhosphodiesterase inhibitoren_US
dc.titleAdequacy of phosphodiesterase inhibitor in prevention and treatment of LPS induced organ failure in BALB/c miceen_US
dc.typeJournal Articleen_US
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