Antioxidant Activities of Phycocyanin: A Bioactive Compound from Spirulina platensis

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dc.contributor.authorGabr, Gamal A.en_US
dc.contributor.authorEl-Sayed, Salwa M.en_US
dc.contributor.authorHikal, Mohamed S.en_US
dc.date.accessioned2020-11-18T10:30:16Z
dc.date.available2020-11-18T10:30:16Z
dc.date.issued2020-03
dc.description.abstractBackground and Objectives:The cyanobacterium Spirulinaalso calledblue green algae is a class of gram negative bacteria which possesses wide range of bioactive colored components as Phycocyanin, carotenoids and chlorophyll. Spirulinais one of the microalgae containing nutrients that havebeen used as a functional food in addition to therapeuticand pharmaceutical applications.This study aimed to evaluate the biochemical composition of Spirulina platensisbiomass and its ethanolic and aqueous extracts, as well as, evaluate the antioxidant activities of the biomass, ethanolic, aqueous and the purified Phycocyanin.Materials and Methods:The chemical compositions of Spirulina platensis were determined, as well as the antioxidant activity of extracts, Phycocyanin, Phycocyanopeptide and Phycocyanobilin using (DPPH) radical-scavenging activity.Results:Results show that biomass has higher total proteins (49.72±0.508%), total carbohydrates (10.3±0.330%), moisture content (7.5±0.685%), lipids (7.2±0.105%) and Minerals (6.9±0.130%).In biomass, the total phenols (51.20±0.25μg/mL) and flavonoids (97.73±1.858 μg/mL) were high compared to the ethanolic (49.48±0.130 and 69.07±1.814 μg/mL) and aqueous (15.27±0.639 and 4.67±0.611 μg/mL) extracts respectively. In the phenolic compounds, pyrogallol was identified as the major compound in biomass and aqueous extract (63.85 and 12.33%) respectively, E-vanillic acid in ethanolic (18.20 %), whereas, hespirdin (3.517 and1.639%) were major flavonoids found in aqueous and ethanolic extracts respectively. The DPPH scavenging activity was found higher in ethanolic extract compared to aqueous while in bioactive, the order of antioxidant activity was Phycocyanin > Phycocyanobilin > Phycocyanopeptide.Conclusions:The study data regarding toSpirulinanutritional value, makesSpirulinaan excellent choice when formulating diets and combating malnutrition. Furthermore, it is a strong antioxidant and could be used as alternative treatments as anticancer, antidiabetic, and anti-inflammatory agent.en_US
dc.identifier.affiliationsDepartment of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam bin AbdulazizUniversity, Al-Kharj, Kingdom of Saudi Arabiaen_US
dc.identifier.affiliationsAgricultural Genetic Engineering Research Institute (AGERI), Agricultural Research Center, Giza, Egypten_US
dc.identifier.affiliationsDepartmentof Agricultural Biochemistry, Faculty of Agriculture, Ain Shams University, Cairo, Egypt.en_US
dc.identifier.affiliationsDepartmentof Agricultural Biochemistry, Faculty of Agriculture, Ain Shams University, Cairo, Egypt.en_US
dc.identifier.citationGabr Gamal A., El-Sayed Salwa M., Hikal Mohamed S.. Antioxidant Activities of Phycocyanin: A Bioactive Compound from Spirulina platensis. Journal of Pharmaceutical Research International. 2020 Mar; 32(2): 73-85en_US
dc.identifier.issn2456-9119
dc.identifier.issn2231-2919
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215845
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber2en_US
dc.relation.volume32en_US
dc.source.urihttps://doi.org/10.9734/JPRI/2020/v32i230407en_US
dc.subjectSpirulina platensisen_US
dc.subjectantioxidantsen_US
dc.subjectchemical compositionen_US
dc.subjectphycocyninen_US
dc.titleAntioxidant Activities of Phycocyanin: A Bioactive Compound from Spirulina platensisen_US
dc.typeJournal Articleen_US
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