Effect of nifedipine and amlodipine on dead space wound healing in rats.

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dc.contributor.authorBhaskar, H Nen_US
dc.contributor.authorUdupa, Saraswathi Len_US
dc.contributor.authorUdupa, A Len_US
dc.date.accessioned2009-05-28T14:35:57Z
dc.date.available2009-05-28T14:35:57Z
dc.date.issued2005-03-09en_US
dc.description.abstractEffect of two calcium channel blockers (CCBs) nifedipine and amlodipine, was studied on normal and steroid depressed wound healing in albino rats, using the dead space wound model. The drugs enhanced normal healing as evidenced by increase in tensile strength of 10 days old granulation tissue. There was neither a significant change in the hydroxyproline level (or collagen) nor a change in the glycosaminoglycan content in granulation tissue. However, lysyloxidase level was increased significantly. The increase in tensile strength could thus be attributed to better cross-linking and maturation of collagen rather than collagen synthesis per se. The drugs were also able to overcome steroid depressed wound healing. It is likely that the prohealing effects may be related to the improved antioxidant status too, since superoxide dismutase levels were observed to be higher in the CCB- treated animals.en_US
dc.description.affiliationDepartment of Pharmacology, Melaka-Manipal Medical College, KMC, MAHE Manipal 576 104, India. bhaskar712001@hotmail.comen_US
dc.identifier.citationBhaskar HN, Udupa SL, Udupa AL. Effect of nifedipine and amlodipine on dead space wound healing in rats. Indian Journal of Experimental Biology. 2005 Mar; 43(3): 294-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/60917
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAmlodipine --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidants --pharmacologyen_US
dc.subject.meshCalcium Channel Blockers --pharmacologyen_US
dc.subject.meshGlycosaminoglycans --metabolismen_US
dc.subject.meshHexosamines --metabolismen_US
dc.subject.meshHexuronic Acids --metabolismen_US
dc.subject.meshHydroxyproline --metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshNifedipine --pharmacologyen_US
dc.subject.meshProtein-Lysine 6-Oxidase --metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSteroids --metabolismen_US
dc.subject.meshSuperoxide Dismutase --metabolismen_US
dc.subject.meshTensile Strengthen_US
dc.subject.meshVasodilator Agents --pharmacologyen_US
dc.subject.meshWound Healing --drug effectsen_US
dc.titleEffect of nifedipine and amlodipine on dead space wound healing in rats.en_US
dc.typeJournal Articleen_US
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