Association between Tpeak-Tend interval/ QT interval (Tp-e/QT ratio) and prognosis in patients with acute pulmonary embolism

dc.contributor.authorRaj, NGen_US
dc.contributor.authorKiran, GRen_US
dc.date.accessioned2019-12-02T09:51:02Z
dc.date.available2019-12-02T09:51:02Z
dc.date.issued2016
dc.description.abstractBackground: Risk stratification of patients with acute pulmonary embolism (PE) allows assessment of individual prognosis and guides therapeutic decision making. Several electrocardiographic (ECG) markers measuring the arrhythmogenic substrate(s) in ventricular myocardium are used to identify the high-risk patients with acute PE. However studies on Tp-e/QT ratio in patients with acute PE are lacking therefore the present study is aimed to evaluate the in hospital prognostic significance (death and in hospital adverse clinical events [ACE]) of Tp-e/QT ratio at admission in acute PE patients. Materials and methods: This was a retrospective study that included adult patients who had been diagnosed with acute PE and were treated at our hospital between January 2012 and March 2016. After considering inclusion and exclusion criteria, data was collected from eligible patients. All ECG recordings were digitalized and evaluated by a computer based program. Tp-e and QT intervals were measured from all precordial leads and mean value is calculated. Statistical analysis was performed using SPSS 17.0. Receiver operator characteristic (ROC) curves were computed for the Tp-e/QT ratio to assess the optimal cutoff values for predicting mortality and ACE. Univariate logistic regression analysis for the predictors of in hospital events (death and in hospital ACE) in the study population was done. The statistical significance was considered for a p-value <0.05. Results: A total of 48 patients were included in the study with mean age of 37.95 years (±13.86) and male: female ratio of 1.18:1. Patients with pulmonary embolism have mean Tp-e/QT ratio of 0.25 and the range of Tp-e/QT ratio was 0.18 to 0.29. In regression analysis, a Tp-e/QT ratio ≥0.26 increased the risk of death (P = 0.03) and a Tp-e/QT ratio ≥0.25 increased the risk of ACE (P = 0.01) significantly.en_US
dc.identifier.affiliationsAssistant Professor, Department of Medicine, MGM Hospital, Warangal, Telangana, India, ndrgururaj@gmail.comen_US
dc.identifier.affiliationsPost Graduate, Department of Medicine, MGM Hospital, Warangal, Telangana, Indiaen_US
dc.identifier.citationRaj NG, Kiran GR. Association between Tpeak-Tend interval/ QT interval (Tp-e/QT ratio) and prognosis in patients with acute pulmonary embolism. International Archives of Integrated Medicine. 2016 Aug; 3(8): 199-205en_US
dc.identifier.issn2394-0026
dc.identifier.issn2394-0034
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/186200
dc.languageenen_US
dc.publisherEducational Society for Excellenceen_US
dc.relation.issuenumber8en_US
dc.relation.volume3en_US
dc.subjectTpeak-Tend intervalen_US
dc.subjectQT intervalen_US
dc.subjectTp-e/QT ratioen_US
dc.subjectPulmonary embolismen_US
dc.subjectPrognosisen_US
dc.titleAssociation between Tpeak-Tend interval/ QT interval (Tp-e/QT ratio) and prognosis in patients with acute pulmonary embolismen_US
dc.typeJournal Articleen_US
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