Identification of T-Cell epitopes in structural proteins of tick borne encephalitis virus for vaccine development.
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Date
2012-04
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Abstract
Tickborne encephalitis (TBE) is a human viral infectious disease caused by tickborne
encephalitis virus (TBEV). It is transmitted by the bite of an infected tick and also initiated the swelling of
brain (encephalitis) and spinal cord. There is a pressing need to develop potent and sufficient amount of
drugs and vaccines for control of TBE. We have selected the structural proteins such as anchored core
protein C, core protein C, premembrane, matrix and envelope proteins of TBEV for identification of T-cell
epitopes using immunoinformatics tools. These epitopes were showed the highest binding affinity with
major histocompatibility complex (MHC) class I and II molecules. These finding may be used as an
immunodiagnostic agent and also development of peptide based novel vaccines.
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Keywords
Tick-borne encephalitis virus, epitopes, MHC, immunodiagnostic, vaccine
Citation
Chaudhary Dharmendra Kumar, Mani Indra, Singh Vijai. Identification of T-Cell epitopes in structural proteins of tick borne encephalitis virus for vaccine development. International Journal of Applied Biology and Pharmaceutical Technology. 2012 Apr-Jun; 3(2): 39-43.