10-year Survival Rate of Laryngeal Cancer Patients in Maharat Nakhon Ratchsima Hospital
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Date
2007-02-04
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Buddhachinaraj Medical Journal
Abstract
PROBLEM/BACKGROUND: Laryngeal cancer is a common malignancy of the head and neck. Favorable prognosis and long-term survival rate is better than other head and neck cancers. OBJECTIVE: To study 5-year and 10-year survival rate of laryngeal cancer patients. RESEARCH DESIGN: A prospective cohort study. SETTING: Department of Otorhinolaryngology, Maharat Nakhon Ratchsima Hospital. MATERIALS and METHOD: Fifteen-year prospective data gathered from medical records of laryngeal cancer patients during January 1992 to December 2006 were analyzed. Data analysis used Kaplan-Meier survival analysis and Cox-regression analysis with significant level at 0.05. RESULTS: Among 248 patients with histologically proven laryngeal cancer (228 males, 20 females) with age range 30-87 (mean 63.49 years); there were supraglottic 38.3%, glottic 25.4%, subglottic 3.2% and transglottic 33.1%. The overall 5-year and 10-year survival rates were 26.1% (95% confidence interval=20.37-32.20) and 19.3% (95% confidence interval=13.93-25.40) respectively. The overall 10-year survival rate by site was 10.9% for supraglottic, 24.0% for glottic, 0% for subglottic and 27.3% for transglottic. The overall 10-year survival rate for stage I through IV was 47.2%, 36.3% 15.2% and 11.5% respectively. CONCLUSIONS: Significant prognostic factors for laryngeal cancer patients are T-stage, N-stage and M-stage. Early diagnosis and treatment are the keys for better survival rates.
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Buddhachinaraj Medical Journal; Vol.24 No.3 September-December 2007; 287-295