Differential microglial and astrocytic response to bacterial and viral infection in the developing hippocampus of neonatal rats.

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dc.contributor.authorPatro, Nisha
dc.contributor.authorSingh, Kavita
dc.contributor.authorPatro, Ishan
dc.date.accessioned2013-11-18T07:09:30Z
dc.date.available2013-11-18T07:09:30Z
dc.date.issued2013-08
dc.description.abstractPolyinosinic:polycytidylic acid (Poly I:C; 5 mg/kg body weight, ip) and lipopolysaccharide (LPS; 0.3 mg/kg body weight, ip) induced microglial and astrocytic activation in Sprague Dawley rats. Higher microglial and astrocytic activities were noticed in Poly I:C infused rats throughout the hippocampus till postnatal day 21 with a comparatively weaker response in LPS group. However, LPS induced inflammation persisted even after postnatal day 21, indicating thereby, that the Poly I:C (viral mimic) produces an acute inflammation, while LPS (bacterial endotoxin) produces chronic inflammation when exposed during early neonatal life.en_US
dc.identifier.citationPatro Nisha, Singh Kavita, Patro Ishan. Differential microglial and astrocytic response to bacterial and viral infection in the developing hippocampus of neonatal rats. Indian Journal of Experimental Biology. 2013 Aug; 51(8): 606-614.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/149363
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/20483en_US
dc.subjectAstrocytesen_US
dc.subjectInfectionsen_US
dc.subjectLipopolysaccharideen_US
dc.subjectMicrogliaen_US
dc.subjectPoly I:Cen_US
dc.subject.meshAcute Disease
dc.subject.meshAnimals
dc.subject.meshAnimals, Newborn
dc.subject.meshAntiviral Agents --pharmacology
dc.subject.meshAstrocytes --drug effects
dc.subject.meshAstrocytes --immunology
dc.subject.meshAstrocytes --metabolism
dc.subject.meshChronic Disease
dc.subject.meshFemale
dc.subject.meshGlial Fibrillary Acidic Protein --metabolism
dc.subject.meshHippocampus --drug effects
dc.subject.meshHippocampus --immunology
dc.subject.meshHippocampus --metabolism
dc.subject.meshImmunoenzyme Techniques
dc.subject.meshInflammation --chemically induced
dc.subject.meshInflammation --immunology
dc.subject.meshInflammation --pathology
dc.subject.meshLipopolysaccharides --pharmacology
dc.subject.meshMicroglia --drug effects
dc.subject.meshMicroglia --immunology
dc.subject.meshMicroglia --metabolism
dc.subject.meshPoly I-C --pharmacology
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.titleDifferential microglial and astrocytic response to bacterial and viral infection in the developing hippocampus of neonatal rats.en_US
dc.typeArticleen_US
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