Clinical Profile and Outcome of H1N1 Influenza Infection at a Tertiary Care Teaching Hospital.

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dc.contributor.authorPatil, Virendra C.en_US
dc.contributor.authorPatil, Harsha V.en_US
dc.contributor.authorKulkarni, Akshay R.en_US
dc.contributor.authorPandere, Kaustubhen_US
dc.contributor.authorVishwanath, Ashwathien_US
dc.date.accessioned2020-11-18T10:25:15Z
dc.date.available2020-11-18T10:25:15Z
dc.date.issued2019-04
dc.description.abstractBackground: The 2009 flu outbreak in humans, knownas "swine influenza" or H1N1 influenza A, refers toinfluenza A due to a new H1N1 strain called SwineOrigin Influenza Virus A (S-OIV). Global pandemicswith high mortality and morbidity occur when avirulent new viral strain emerges. Aim and Objectives:To study demography, clinical profile and outcome ofH1N1 influenza infection at a tertiary care teachinghospital. Material and Methods: This was aprospective observational study conducted at theteaching hospital during six month period. It was a timest bound study over a period of six months (from 1 Julyth 2018 to 30 December 2018). All suspects with throatswab/nasal swab positive for influenza H1N1 virus byReverse Transcriptase Polymerase Chain Reaction(RT-PCR) with age more than 15 years were includedin the present study. Data were analysed for mean,percentage, standard deviation and Chi square test forquantitative data by using Microsoft Excel spreadsheet. Results: A total 60 patients were admitted withconfirmed diagnosis of H1N1 infection. Out of the 21(35%) were males and 39 (65%) were females,predominated by female gender (p=0.001). The meanage in male (46.14 ± 20.058) was relatively morecompared to female gender (36.33 ± 11.50). The malegender had more co-morbidities and risk factorscompared to female patients (p=0.01) and wasstatistically significant. Out of total 21 male patients 7patients died because of bilateral pneumonia and AcuteRespiratory Distress Syndrome (ARDS) and MultiOrgan Dysfunction (MOD) with case fatality rate of33.33%. Out of total 39 female patients 5 patients diedwith case fatality rate of 12.82%. Conclusion: Thepresent study highlighted the disease burdenassociated with H1N1 infection. The advancing age,male gender, associated co-morbidities and delayedpresentation were the risk factors for mortality inpresent cohort study of H1N1 patients. The communityawareness, early case detection and timelymanagement can reduce the disease burden at largeen_US
dc.identifier.affiliationsDepartment of Medicine, Department of Microbiology, Krishna Institute of Medical Sciences, Karad415110 (Maharashtra) Indiaen_US
dc.identifier.citationPatil Virendra C., Patil Harsha V., Kulkarni Akshay R., Pandere Kaustubh, Vishwanath Ashwathi. Clinical Profile and Outcome of H1N1 Influenza Infection at a Tertiary Care Teaching Hospital.. Journal of Krishna Institute of Medical Sciences University. 2019 Apr; 8(2): 53-62en_US
dc.identifier.issn2231-4261
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215603
dc.languageenen_US
dc.publisherKrishna Institute of Medical Sciences Universityen_US
dc.relation.issuenumber2en_US
dc.relation.volume8en_US
dc.source.urihttps://www.jkimsu.com/jkimsu-vol8no2/JKIMSU,%20Vol.%208,%20No.%202,%20April-June%202019%20Page%2053-62.pdfen_US
dc.subjectSwine influenzaen_US
dc.subjectH1N1en_US
dc.subjectBilateral pneumoniaen_US
dc.subjectAcute Respiratory Distress Syndromeen_US
dc.subjectMulti-Organ Dysfunctionen_US
dc.titleClinical Profile and Outcome of H1N1 Influenza Infection at a Tertiary Care Teaching Hospital.en_US
dc.typeJournal Articleen_US
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