Clinical Profile and Outcome of H1N1 Influenza Infection at a Tertiary Care Teaching Hospital.

Patil, Virendra C.; Patil, Harsha V.; Kulkarni, Akshay R.; Pandere, Kaustubh; Vishwanath, Ashwathi

Clinical Profile and Outcome of H1N1 Influenza Infection at a Tertiary Care Teaching Hospital.

Date

2019-04

Authors

Publisher

Krishna Institute of Medical Sciences University

Abstract

Background: The 2009 flu outbreak in humans, knownas "swine influenza" or H1N1 influenza A, refers toinfluenza A due to a new H1N1 strain called SwineOrigin Influenza Virus A (S-OIV). Global pandemicswith high mortality and morbidity occur when avirulent new viral strain emerges. Aim and Objectives:To study demography, clinical profile and outcome ofH1N1 influenza infection at a tertiary care teachinghospital. Material and Methods: This was aprospective observational study conducted at theteaching hospital during six month period. It was a timest bound study over a period of six months (from 1 Julyth 2018 to 30 December 2018). All suspects with throatswab/nasal swab positive for influenza H1N1 virus byReverse Transcriptase Polymerase Chain Reaction(RT-PCR) with age more than 15 years were includedin the present study. Data were analysed for mean,percentage, standard deviation and Chi square test forquantitative data by using Microsoft Excel spreadsheet. Results: A total 60 patients were admitted withconfirmed diagnosis of H1N1 infection. Out of the 21(35%) were males and 39 (65%) were females,predominated by female gender (p=0.001). The meanage in male (46.14 ± 20.058) was relatively morecompared to female gender (36.33 ± 11.50). The malegender had more co-morbidities and risk factorscompared to female patients (p=0.01) and wasstatistically significant. Out of total 21 male patients 7patients died because of bilateral pneumonia and AcuteRespiratory Distress Syndrome (ARDS) and MultiOrgan Dysfunction (MOD) with case fatality rate of33.33%. Out of total 39 female patients 5 patients diedwith case fatality rate of 12.82%. Conclusion: Thepresent study highlighted the disease burdenassociated with H1N1 infection. The advancing age,male gender, associated co-morbidities and delayedpresentation were the risk factors for mortality inpresent cohort study of H1N1 patients. The communityawareness, early case detection and timelymanagement can reduce the disease burden at large

Keywords

Swine influenza, H1N1, Bilateral pneumonia, Acute Respiratory Distress Syndrome, Multi-Organ Dysfunction

Citation

Patil Virendra C., Patil Harsha V., Kulkarni Akshay R., Pandere Kaustubh, Vishwanath Ashwathi. Clinical Profile and Outcome of H1N1 Influenza Infection at a Tertiary Care Teaching Hospital.. Journal of Krishna Institute of Medical Sciences University. 2019 Apr; 8(2): 53-62