Innovations in tablet coating technology: A review.
Loading...
Date
2011-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Solid dosage forms are coated for a number of reasons, the most important of
which is controlling the release profiles and bioavailability of the active ingredient. The amount
of coating on the surface of a tablet is critical to the effectiveness of the oral dosage form. Tablets
are usually coated in horizontal rotating pans with the coating sprayed onto the free surface of the
tablet bed. Tablets must have a coating mass that lies within a prescribed range with very little
inter- and intra-tablet coating variability. Using the Discrete Element Method (DEM), tablet
coating can be simulated on the computer. Simulation data provide the position, velocity, and
orientation of each tablet within the coater, allowing accurate measurements of the time and
orientation that each tablet spends exposed to the coating spray.
Description
Keywords
Bioavailability, Rotating pans, Discrete element method (DEM), Spray pattern, spray mass flow rate
Citation
Kamble Neelam D, Chaudhari Prafulla S, Oswal Rajesh J, Kshirsagar Sandip S, Antre Rishikesh V. Innovations in tablet coating technology: A review. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Jan-Mar; 2(1): 214-218.