Abnormalities of Hemoglobin and Glucose-6-Phosphate-Dehydrogenase Deficiency in Children with Uncomplicated Malaria and Living in Banfora and Saponé, Two Different Malaria Setting of Burkina Faso

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dc.contributor.authorBadoum, Emilie S.en_US
dc.contributor.authorSermé, Samuel S.en_US
dc.contributor.authorYaro, Jean B.en_US
dc.contributor.authorSam, A. Coulibalyen_US
dc.contributor.authorDésiré, Kargougouen_US
dc.contributor.authorAmidou, Diarraen_US
dc.contributor.authorAmidou, Z. Ouédraogoen_US
dc.contributor.authorLankoande, Maliken_US
dc.contributor.authorIssa, Nébiéen_US
dc.contributor.authorIssiaka, Soulamaen_US
dc.contributor.authorAlphonse, Ouédraogoen_US
dc.contributor.authorAlfred, B. Tionoen_US
dc.contributor.authorYves, Traoréen_US
dc.contributor.authorSodiomon, B. Sirimaen_US
dc.contributor.authorEdith, C. Bougoumaen_US
dc.date.accessioned2020-10-16T08:44:15Z
dc.date.available2020-10-16T08:44:15Z
dc.date.issued2019-07
dc.description.abstractAims:The aim of this study is to assess the prevalence of hemoglobin abnormalities and G6PD deficiency and their respective influence on anemia occurring in less than five years old children with clinical P. falciparummalaria living in Burkina Faso.Study Design:The study was a cross-sectional survey with descriptive focus conducted from December 2010 to January 2013 in Saponé health district and from May to October 2011 in Banforahealth district. Clinical and laboratory data were collected. Blood smears on slides for malaria diagnosis by microscopy, hemoglobin level and filter paper for the detection of human genetic factors were performed.Methodology:A total of 386 subjects from Saponé (131) and Banfora (255) were enrolled. DNA collected from each sample was extracted using chelex-100 method and the human genetic resistance factors background was assessed by RFLP-PCR. Abnormal hemoglobin patients were classified as NonAA while AA was defined the normal hemoglobin.Results:In this study, 70.98% (274/386) were classified normal hemoglobin (AA) while 29.02% (112/386) of subjects were carrying at least one abnormal (NonAA) allele: 24.35%AC, 3.63% AS, 0.78%CC and 0.26%SC. G6PD deficiency was 9.59% (37/386) among which, 4.92% for male and 4.66% in female. However, this gender difference was not statistically significant (p=1.00). 319/367 (86.92%) of the patients were anemic (59.4% with moderate anemia and 20.98% with mild anemia). Theprevalence of anemia in G6PD deficient subjects was 83.33% (of which 58.33% were moderate anemia and 22.22% mild anemia). The difference between types of hemoglobin (p=0.64) in the occurrence of anemia (AA 87.64% and Non AA 85.18%) was not statistically significant. Conclusion:This study showed that the prevalence of these genetic factors was relatively low among children with clinical falciparummalaria with high parasite density. In addition, these factors appear to have no effect on anemia.en_US
dc.identifier.affiliationsDepartment of Biochemistry and Microbiology, Laboratoire de Biochimie et d’Immunologie Appliquée,Université Joseph Ki-Zerbo, Burkina Fasoen_US
dc.identifier.affiliationsCentre National de Recherche et de Formation sur le Paludisme(CNRFP), Ouagadougou, Burkina Fasoen_US
dc.identifier.affiliationsCentre National de Recherche et de Formation sur le Paludisme(CNRFP), Ouagadougou, Burkina Fasoen_US
dc.identifier.affiliationsCentre National de Recherche et de Formation sur le Paludisme(CNRFP), Ouagadougou, Burkina Fasoen_US
dc.identifier.affiliationsCentre National de Recherche et de Formation sur le Paludisme(CNRFP), Ouagadougou, Burkina Fasoen_US
dc.identifier.affiliationsCentre National de Recherche et de Formation sur le Paludisme(CNRFP), Ouagadougou, Burkina Fasoen_US
dc.identifier.affiliationsCentre National de Recherche et de Formation sur le Paludisme(CNRFP), Ouagadougou, Burkina Fasoen_US
dc.identifier.affiliationsCentre National de Recherche et de Formation sur le Paludisme(CNRFP), Ouagadougou, Burkina Fasoen_US
dc.identifier.affiliationsCentre National de Recherche et de Formation sur le Paludisme(CNRFP), Ouagadougou, Burkina Fasoen_US
dc.identifier.affiliationsCentre National de Recherche et de Formation sur le Paludisme(CNRFP), Ouagadougou, Burkina Fasoen_US
dc.identifier.affiliationsCentre National de Recherche et de Formation sur le Paludisme(CNRFP), Ouagadougou, Burkina Fasoen_US
dc.identifier.affiliationsCentre National de Recherche et de Formation sur le Paludisme(CNRFP), Ouagadougou, Burkina Fasoen_US
dc.identifier.affiliationsCentre National de Recherche et de Formation sur le Paludisme(CNRFP), Ouagadougou, Burkina Fasoen_US
dc.identifier.affiliationsGroupe de Recherche Action en Santé (GRAS), Burkina Fasoen_US
dc.identifier.citationBadoum Emilie S., Sermé Samuel S., Yaro Jean B., Sam A. Coulibaly, Désiré Kargougou, Amidou Diarra, Amidou Z. Ouédraogo, Lankoande Malik, Issa Nébié, Issiaka Soulama, Alphonse Ouédraogo, Alfred B. Tiono, Yves Traoré, Sodiomon B. Sirima, Edith C. Bougouma. Abnormalities of Hemoglobin and Glucose-6-Phosphate-Dehydrogenase Deficiency in Children with Uncomplicated Malaria and Living in Banfora and Saponé, Two Different Malaria Setting of Burkina Faso. International Journal of TROPICAL DISEASE & Health. 2019 Jul; 37(3): 1-10en_US
dc.identifier.issn2278–1005
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/209575
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber3en_US
dc.relation.volume37en_US
dc.source.urihttps://dx.doi.org//10.9734/IJTDH/2019/v37i130168en_US
dc.subjectPrevalenceen_US
dc.subjecthemoglobinen_US
dc.subjectG6PDen_US
dc.subjectchildrenen_US
dc.subjectmalariaen_US
dc.subjectBurkina Fasoen_US
dc.titleAbnormalities of Hemoglobin and Glucose-6-Phosphate-Dehydrogenase Deficiency in Children with Uncomplicated Malaria and Living in Banfora and Saponé, Two Different Malaria Setting of Burkina Fasoen_US
dc.typeJournal Articleen_US
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