Damage induction by direct electric current in tumoural target cells.

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dc.contributor.authorHolandino, Cen_US
dc.contributor.authorVeiga, V Fen_US
dc.contributor.authorCapella, M Men_US
dc.contributor.authorMenezes, Sen_US
dc.contributor.authorAlviano, C Sen_US
dc.date.accessioned2009-05-28T14:09:53Z
dc.date.available2009-05-28T14:09:53Z
dc.date.issued2000-06-16en_US
dc.description.abstractDamage induction to tumour target cells (P815) by direct electric current (DC) was investigated. A 6 min treatment of P815 cells with DC generated decreased levels of cell viability and proliferation. The ultrastructural analysis of DC-treated cells revealed the presence of blebs, loss of cell surface filopodia, and ruptures in cell membrane. Mitochondrial alterations, swelling of cells, cytoplasmic matrix rarefaction, and cellular debri formation were also observed. The study shows that tumoural target cells can be damaged by direct electric current and this approach may provide means to understand the mechanism of tumour regression induced by electrochemical therapy.en_US
dc.description.affiliationDepartamento de Medicamentos-Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.en_US
dc.identifier.citationHolandino C, Veiga VF, Capella MM, Menezes S, Alviano CS. Damage induction by direct electric current in tumoural target cells. Indian Journal of Experimental Biology. 2000 Jun; 38(6): 554-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/60353
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Deathen_US
dc.subject.meshCell Divisionen_US
dc.subject.meshElectric Stimulation Therapyen_US
dc.subject.meshElectricityen_US
dc.subject.meshMast-Cell Sarcoma --pathologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMicroscopy, Electronen_US
dc.subject.meshTumor Cells, Cultured --ultrastructureen_US
dc.titleDamage induction by direct electric current in tumoural target cells.en_US
dc.typeEvaluation Studiesen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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