A study of her-2/ neu oncogene expression in benign and malignant ovarian tumors

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dc.contributor.authorGupta, Sen_US
dc.contributor.authorMehra, Men_US
dc.contributor.authorKhattri, Jen_US
dc.contributor.authorMadhvi, Men_US
dc.date.accessioned2020-09-24T07:54:36Z
dc.date.available2020-09-24T07:54:36Z
dc.date.issued2020-04
dc.description.abstractBackground: Ovarian cancers are very common worldwide with serous epithelial tumors being the most common. Her-2/neuprotoncogene encodes a protein belonging to the EGFR tyrosine kinase receptor family. Overexpression has been shown for poor prognosis in breast cancer. The study was done to find the association of ovarian tumors with Her-2/neu expression. Aim and objectives: To assess the clinicopathological profile of various ovarian tumors with special reference to age, histological type, grade, and stage of the tumor. To assess and compare the expression of Her-2/neu oncogene in benign and malignant ovarian tumors in relation to age, histological type, grade, and stage of the tumor. Method: The prospective study was done on 37 specimens received in the Department of Pathology; NIMS medical college from the period between 2015 to 2019. Results: All the benign and borderline tumors were negative for her-2/neu .48.6% of malignant tumors were her-2/neu positive. Conclusion: Her-2/neu positivity was seen in 24.3% of ovarian tumors. All the benign and borderline tumors were negative for her-2/neu. 48.6% of malignant tumors were her-2/neu positive.en_US
dc.identifier.affiliationsDr. Sumit Gupta Associate Professor, Department of Pathology, N.I.M.S Medical College, Jaipur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDr Manju Mehra Professor, Department of Pathology, N.I.M.S Medical College, Jaipur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDr Jyotsana Khattri Assistant Professor, Department of Pathology, N.I.M.S Medical College, Jaipur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDr Madhvi Junior Resident, Department of Pathology, N.I.M.S Medical College, Jaipur, Rajasthan, Indiaen_US
dc.identifier.citationGupta S, Mehra M, Khattri J, Madhvi M. A study of her-2/ neu oncogene expression in benign and malignant ovarian tumors. International Journal of Medical Research & Review. 2020 Apr; 8(2): 169-175en_US
dc.identifier.issn2320-8686
dc.identifier.issn2321-127X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/205342
dc.languageenen_US
dc.publisherSiddharth Health Research and Social Welfare Societyen_US
dc.relation.issuenumber2en_US
dc.relation.volume8en_US
dc.source.urihttps://doi.org/10.17511/ijmrr.2020.i02.06en_US
dc.subjectHer-2/neuprotoncogeneen_US
dc.subjectOvarian canceren_US
dc.subjectEpithelial tumorsen_US
dc.titleA study of her-2/ neu oncogene expression in benign and malignant ovarian tumorsen_US
dc.typeJournal Articleen_US
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