Elm Oyster mushroom Hypsizygus ulmarius (Bull.:Fr.) attenuates carbon tetrachloride induced hepatic injury in Wistar rats

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dc.contributor.authorGreeshma, Panavalappilen_US
dc.contributor.authorFeba, Joseen_US
dc.contributor.authorZuhara, Fathimathu Karattuthodien_US
dc.contributor.authorJanardhanan, Kainoor Krishnankuttyen_US
dc.date.accessioned2020-01-02T06:38:43Z
dc.date.available2020-01-02T06:38:43Z
dc.date.issued2019-10
dc.description.abstractLiver is a vital organ of the body that manages metabolic disposition of drugs and other foreign substances. Liver damage is one of the major causes of human mortality. Natural products including mushrooms have gained researchers’ attention as the source of for drugs to treat liver diseases. In this context, here, we examined hepatoprotective activity of ethanolic extracts of the fruiting bodies and mycelia of the Elm oyster Hypsizygus ulmarius. Carbon tetrachloride was used to induce hepatic injury and silymarin served as standard drug. Hepatoprotection was evaluated by determining the activities of liver function enzymes, antioxidant status and the histopathological changes in liver tissue of experimental animals. Treatment with the extracts decreased elevated liver function enzymes, such as serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase and alkaline phosphatase and also enhanced depleted antioxidant levels in liver tissue. The histopathological observations supported these findings. The results suggested the potential use of elm oyster mushroom to prevent liver disorders.en_US
dc.identifier.affiliationsDepartment of Microbiology, Amala Cancer Research Centre (Affiliated to University of Calicut), Amala Nagar, Thrissur-680 555, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Life Sciences, University of Calicut, Thenjippalam, Malappuram, Kerala, Indiaen_US
dc.identifier.citationGreeshma Panavalappil, Feba Jose, Zuhara Fathimathu Karattuthodi, Janardhanan Kainoor Krishnankutty. Presence of integrase core domain in mutant type black pepper Piper nigrum L. ‘Thekken’ with altered inflorescence architecture. Indian Journal of Experimental Biology. 2019 Oct; 57(10): 774-779en_US
dc.identifier.issn0975-1009
dc.identifier.issn0019-5189
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/191521
dc.languageenen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.relation.issuenumber10en_US
dc.relation.volume57en_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/50561en_US
dc.titleElm Oyster mushroom Hypsizygus ulmarius (Bull.:Fr.) attenuates carbon tetrachloride induced hepatic injury in Wistar ratsen_US
dc.typeJournal Articleen_US
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