Serum phosphorus levels as a predictor and severity marker for mechanical ventilation in adults versus elderly patients – A cross-sectional study
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Date
2024-07
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National Academy of Medical Sciences
Abstract
Objectives: Mechanical ventilation (MV) is a supportive therapy for patients with acute respiratory failure. Studies have shown direct relationship between serum phosphorus on admission and risk of respiratory failure requiring MV. This study aims to determine admission serum phosphorus level’s ability to predict severity in 64 mechanically ventilated patients among two groups: Group A was designated to adults (<60 years of age) and Group B to elderly (60 years or older) admitted to the critical care unit (CCU). Study Design: It is a cross-sectional study. Material and Methods: Data were collected from 64 adults admitted to CCU. The Sequential Organ Failure Assessment (SOFA) score and serum Phosphorus level on admission were assessed. Patients with Diabetic Ketoacidosis, Head Trauma, Renal Failure, Hyper or Hypoparathyroidism, Leukaemia, and Lymphoma were excluded. Results: The study had 32 subjects in each group. The commonest indication for mechanical ventilation was Poisoning (31.25%) in Group A and Cerebrovascular Accident (34.37%) in Group B. The common complication among the study group was ventilator- associated pneumonia (14.06%). Out of 64 patients requiring mechanical ventilation, nine patients had hypophosphatemia, and eighteen had hyperphosphatemia. In the case of hypophosphatemia, 100% and in hyperphosphatemia, 55.5% mortality was observed. Conclusion: Altered serum phosphorus levels on admission can be a potential indicator for requiring MV and mortality. Both hypophosphatemia and hyperphosphatemia are potential risk factors for the development of respiratory failure. Also, age-related variation in phosphorus levels has not shown any association with the outcome.
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Keywords
Mechanical ventilation, Mortality, Serum phosphorus, SOFA score, Adults, Elderly
Citation
Ambali AP, Tomar P, Shivanand LK . Serum phosphorus levels as a predictor and severity marker for mechanical ventilation in adults versus elderly patients – A cross-sectional study . Annals of the National Academy of Medical Sciences (India). 2024 Jul; 60(3): 201-205