Effects of low concentrations of a polychlorinated biphenyl, Aroclor 1254 on membrane bound ion dependent ATPases in mice liver.

Simple item page
dc.contributor.authorPathak, Shweta
dc.contributor.authorKundu, Rahul
dc.date.accessioned2013-07-31T09:01:19Z
dc.date.available2013-07-31T09:01:19Z
dc.date.issued2013-06
dc.description.abstractAroclor 1254, a polychlorinated biphenyl, is present in the environment in low concentration but references on its toxic effects on liver cell membrane proteins and the mechanism of actions are not abundantly available. Therefore, the present study was undertaken to investigate the low level, sub-acute dose and exposure duration dependent effects of Aroclor 1254 on total, Na+, K+, Ca2+ and Mg2+-ATPases of the mouse liver. The hypotheses tested in the present study were, (a) whether the low, environmentally available dose and the exposure durations of Aroclor 1254 affects the membrane-bound ion dependent ATPases, and (b) if a response was observed, whether it is a direct or indirect effects of the toxicant. Groups of mice were exposed to different doses (0.1 and 1mg kg-1 body weight d-1) and exposure durations (4 d, 8 d and 12 d) of Aroclor 1254. The results indicated significant exposure duration dependent changes in the specific activity of the selected membrane bound ATPases. As the observed changes were mostly enzyme stimulation after toxication through oral administration, the effects of the Aroclor were possibly indirect, through complex chain of reactions.en_US
dc.identifier.citationPathak Shweta, Kundu Rahul. Effects of low concentrations of a polychlorinated biphenyl, Aroclor 1254 on membrane bound ion dependent ATPases in mice liver. Indian Journal of Experimental Biology. 2013 Jun; 51(6): 477-480.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/147617
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/18666en_US
dc.subjectAroclor 1254en_US
dc.subjectATPasesen_US
dc.subjectLiveren_US
dc.subjectMiceen_US
dc.subject.meshAdenosine Triphosphatases --drug effects
dc.subject.meshAdenosine Triphosphatases --metabolism
dc.subject.meshAnimals
dc.subject.meshAntithyroid Agents --pharmacology
dc.subject.meshCell Membrane --drug effects
dc.subject.meshCell Membrane --enzymology
dc.subject.meshChlorodiphenyl (54% Chlorine) --pharmacology
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshLiver --drug effects
dc.subject.meshLiver --enzymology
dc.subject.meshMale
dc.subject.meshMice
dc.titleEffects of low concentrations of a polychlorinated biphenyl, Aroclor 1254 on membrane bound ion dependent ATPases in mice liver.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijeb2013v51n6p477.pdf
Size:
95.81 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Experimental Biology