Development And Validation Of Uv-Visible Spectrophotmetric Method For The Simultaneous Estimation Of Emtricitabine And Tenofovir Alafenamide In Bulk And Tablet Dosage Form
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Date
2019-06
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Bimonthly published online Journal
Abstract
Abstract: A simple, rapid, accurate and economical method has been developed for thesimultaneous estimation of Emtricitabine and Tenofovir Alafenamide in tablet dosage form.The linearity of the method was found to be in the range of 10.8µg/ml- 12.8µg/ml forTenofovir Alafenamide and 86.4µg/ml-102.4µg/ml for Emtricitabine. From the developedmethod the drugs showed maximum absorbance at 263 and 281nm for Tenofovir Alafenamideand Emtricitabine respectively. The percentage purity of the drugs was found as 96.8 and97.6%w/w for Tenofovir Alafenamide and Emtricitabine respectively. The method was alsofound to be accurate, precise, robust and rugged. The limit of detection and the limit ofquantification were found to be 0.234µg/ml and 0.710µg/ml for Tenofovir Alafenamide and2.25µg/ml and 6.83µg/ml for Emtricitabine respectively..
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Keywords
Tenofovir Alafenamide (TEN), Emtricitabine (EMT), UV-Visible spectroscopy
Citation
Ebin Cj, Sheeja Vk. Development And Validation Of Uv-Visible Spectrophotmetric Method For The Simultaneous Estimation Of Emtricitabine And Tenofovir Alafenamide In Bulk And Tablet Dosage Form. International Journal of Pharmaceutical Research and Bioscience (IJPRBS). 2019 Jun; 8(3): 1-9