A clinical study of neurological manifestations in HIV positive patients in a tertiary care hospital of Telangana, India

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dc.contributor.authorKumar, Kamera Sateeshen_US
dc.contributor.authorNarisetty, Veenaen_US
dc.contributor.authorShekar, P. Chandraen_US
dc.contributor.authorChangala, Praveenen_US
dc.contributor.authorAlluri, Neeraja.en_US
dc.date.accessioned2019-12-02T10:08:38Z
dc.date.available2019-12-02T10:08:38Z
dc.date.issued2018
dc.description.abstractBackground: Human Immunodeficiency Virus (HIV) infection is a global pandemic, India has second largest burden of HIV illness. Nervous system is most frequent and serious target of HIV infection. Aim: The main aim of our study was to evaluate the occurrence of various neurological manifestations in HIV positive patients and to correlate them with CD4 count at the time of presentation. Materials and methods: This prospective study was carried out for a period of 2 years from January 2014 to December 2016 in the Department of Neurology, Gandhi Hospital, Hyderabad, India. Those patients, who satisfied the inclusion criteria (>18 year of age; HIV positive; any gender) were included in our study. Patients who were HIV positive but having non neurological medical conditions were excluded. Those with various neurological symptoms were subjected to thorough neurological examination, whenever indicated neuroimaging, CSF analysis, NCS, Toxoplasma serology were done. CD4 count was done in all patients. KameraSateesh Kumar, VeenaNarisetty, P. Chandra Shekar, Changala Praveen, AlluriNeeraja. A clinical study of neurological manifestations in HIV positive patients in a tertiary care hospital of Telangana, India. IAIM, 2018; 5(1): 42-49. Page 43 Results: Our study enrolled a total of 1011 HIV positive patients, out of them 354(35%) patients had neurological manifestations. Among them, 239 (67.51%) were male and115 (32.48%) were female. We analyzed patients presented with various neurological symptoms, 187(52%) patients presented with parasthesias. CD4 count was done to all patients. Out of 354 patients, 188 (39.4%) patients had low CD4 count (<200μL). NCS was abnormal in 182 (51.4%) patients. Axonal sensory neuropathy was the most common abnormality found in 82 (45.0%) patients. The most common neurological manifestation was peripheral neuropathy, seen in 166 (46.8%) patients. Conclusion: HIV infection can affect all levels of the neuronal axis. Neurological manifestations are common in 4th decade of life and males affect more than females. Peripheral neuropathy was the most common neurological manifestation and Tuberculosis was the prominent infectious etiology. Neurological manifestations are seen with low CD4 count and there is a significant correlation between them hence can be stated that, these are the manifestations of the late stage of the disease.en_US
dc.identifier.affiliationsAssistant Professor, Gandhi Medical College/ Gandhi Hospital, Secunderabad, Hyderabad, Telangana, India, sateeshkamera@yahoo.comen_US
dc.identifier.affiliationsProfessor and Head, Department of Neurology, Gandhi Medical College/ Gandhi Hospital, Secunderabad, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsPost Graduate, Gandhi Medical College/ Gandhi Hospital, Secunderabad, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsPost Graduate, Gandhi Medical College/ Gandhi Hospital, Secunderabad, Hyderabad, Telangana, Indiaen_US
dc.identifier.citationKumar Kamera Sateesh, Narisetty Veena, Shekar P. Chandra, Changala Praveen, Alluri Neeraja.. A clinical study of neurological manifestations in HIV positive patients in a tertiary care hospital of Telangana, India. International Archives of Integrated Medicine. 2018 Jan; 5(1): 42-49en_US
dc.identifier.issn2394-0026
dc.identifier.issn2394-0034
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/186998
dc.languageenen_US
dc.publisherEducational Society for Excellenceen_US
dc.relation.issuenumber1en_US
dc.relation.volume5en_US
dc.subjectHIV positive patientsen_US
dc.subjectNeurological manifestationsen_US
dc.subjectCD4 counten_US
dc.subjectPeripheral neuropathyen_US
dc.subjectTuberculosisen_US
dc.titleA clinical study of neurological manifestations in HIV positive patients in a tertiary care hospital of Telangana, Indiaen_US
dc.typeJournal Articleen_US
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