Isolation of Candida albicans among HIV Patients Presenting with Oral Thrush in Abuja, Nigeria

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dc.contributor.authorYunusaen_US
dc.contributor.authorThairuen_US
dc.contributor.authorUkonuen_US
dc.contributor.authorBob, Agwuen_US
dc.contributor.authorAdeoye, Aisha Mashooden_US
dc.date.accessioned2020-10-16T08:52:36Z
dc.date.available2020-10-16T08:52:36Z
dc.date.issued2019-07
dc.description.abstractBackground: Candida infections are known contributors to the high morbidity and mortality rates seen in HIV positive patients.Methodology: This was a descriptive cross-sectional study. The study was carried out at the Microbiology research laboratory, department of Medical Microbiology, University of Abuja Teaching Hospital, Gwagwalada. The population is made up of two hundred and ten (210) patients who presented with oral thrush between fifteen years and seventy years which comprises of 160 HIV seropositive and 50 non age and sex matched HIV seronegative patients. Culture, Microscopy and ELISA methods were used for isolation of Candida albicans. An interviewer-administered, structured questionnaire was used as the study tool Results: The mean age for the isolation of Candida albicanswas 30 ± 18.7 years, with the highest proportion of isolates within the age range of 21-30 years accounting for 27.1% of the study population recruited and the lowest proportion of isolates being 41-50 years accounting for 8.0%.From the 210 subjects withCandida albicansin the study, one hundred and sixty (160) representing 76.2 were isolated from HIV seropositive clients and Candida albicansisolation rate among HIV seronegative population was 23.8%.Conclusion: The sensitivity, specificity and positivepredictive value of using Grams reaction methods in the diagnosis of Candida albicanswas 22.9%, 95.2% and 82.6%. The sensitivity, specificity and positive predictive value of using ELISA methods was 25.7%, 86.7% and 65.9%.In this study, there was preponderance of Candida albicansisolate among the young and the old in HIV seropositive patients but largely isolated from older patients among HIV seronegative patientsen_US
dc.identifier.affiliationsDepartment of Microbiology and Parasitology, University of Abuja / University of Abuja Teaching Hospital, Gwagwalada, Abuja, Federal Capital Territory, Nigeriaen_US
dc.identifier.affiliationsDermatology Unit, Department of Internal Medicine, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Federal Capital Territory, Nigeriaen_US
dc.identifier.affiliationsDepartment of Microbiology and Parasitology, University of Abuja, Gwagwalada, Abuja, Federal Capital Territory, Nigeriaen_US
dc.identifier.citationYunusa, Thairu, Ukonu, Bob Agwu, Adeoye Aisha Mashood. Isolation of Candida albicans among HIV Patients Presenting with Oral Thrush in Abuja, Nigeria. Journal of Advances in Medicine and Medical Research. 2019 Jul; 30(1): 1-8en_US
dc.identifier.issn2456-8899
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210154
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber1en_US
dc.relation.volume30en_US
dc.source.urihttps://dx.doi.org//10.9734/JAMMR/2019/v30i130157en_US
dc.subjectIsolation methodsen_US
dc.subjectCandida albicansen_US
dc.subjectoral candidiasisen_US
dc.subjectHIV patientsen_US
dc.titleIsolation of Candida albicans among HIV Patients Presenting with Oral Thrush in Abuja, Nigeriaen_US
dc.typeJournal Articleen_US
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