Bioactive extract of mycelia biomass of Ganoderma lucidum protects doxorubicin induced cardiomyopathy

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dc.contributor.authorVeena, Ravindran Ken_US
dc.contributor.authorAjith, Thekkuttuparambil Aen_US
dc.contributor.authorJanardhanan, kainoor Krishnankuttyen_US
dc.date.accessioned2023-08-09T06:20:52Z
dc.date.available2023-08-09T06:20:52Z
dc.date.issued2022-08
dc.description.abstractCardiotoxicity induced by anticancer drug; doxorubicin (DOX) is a limiting factor for its prolonged use in chemotherapy. No effective drug is currently available to prevent DOX induced cardiomyopathy. Ganoderma lucidum is highly valued medicinal mushroom used in traditional medicine. Mycelia biomasses are considered as alternate sources of mushroom bioactive compounds. We examined the effect of bioactive extract of G. lucidum mycelia biomass (GLME) to prevent cardiotoxicity induced by DOX in rats using a cumulative dose 18 mg/kg body wt. GLME was administered to animals at doses of 250 and 500 mg/kg body wt. once daily for five days prior to DOX administration and continued for three more days. Animals were sacrificed 24 h after the last dose of drug. Activities of creatine kinase (CK), lactate dehydrogenase (LDH), endogenous antioxidant status, oxidative stress markers, electrocardiograph (ECG) and haematological parameters were evaluated. DOX administration drastically elevated CK, LDH, myocardial peroxidation and oxidative stress and significantly lowered endogenous antioxidant activity. GLME administration attenuated elevated levels of CK, LDH and oxidative stress and also ameliorated alterations in haematological and ECG parameters. Results revealed that bioactive extract of G. lucidum mycelia imparted significant protection against DOX induced cardiomyopathy suggesting the potential therapeutic significance of G. lucidum mycelia bioactives to alleviate DOX induced cardiomyopathy.en_US
dc.identifier.affiliationsDepartment of Microbiology, Amala Cancer Research Centre;en_US
dc.identifier.affiliationsDepartment of Biochemistry, Amala Institute of Medical Sciences, Amala Nagar, Thrissur-680 555, Kerala, Indiaen_US
dc.identifier.citationVeena Ravindran K, Ajith Thekkuttuparambil A, Janardhanan kainoor Krishnankutty. Bioactive extract of mycelia biomass of Ganoderma lucidum protects doxorubicin induced cardiomyopathy. Indian Journal of Experimental Biology. 2022 Aug; 60(8): 587-596en_US
dc.identifier.issn0975-1009
dc.identifier.issn0019-5189
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/222521
dc.languageenen_US
dc.publisherCSIR-NIScPRen_US
dc.relation.issuenumber8en_US
dc.relation.volume60en_US
dc.source.urihttps://doi.org/10.56042/ijeb.v60i08.35341en_US
dc.subjectAnticancer drug toxicityen_US
dc.subjectChemotherapyen_US
dc.subjectCardiac injury markersen_US
dc.subjectLingzhien_US
dc.subjectMushroomen_US
dc.subjectOxidative stressen_US
dc.subjectReishien_US
dc.titleBioactive extract of mycelia biomass of Ganoderma lucidum protects doxorubicin induced cardiomyopathyen_US
dc.typeJournal Articleen_US
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