High diversity in the vaginal microbiome in women following preterm premature rupture of membranes and its effect on fetomaternal outcome

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dc.contributor.authorJhirwal, M.en_US
dc.contributor.authorSingh, P.en_US
dc.contributor.authorShekhar, S.en_US
dc.contributor.authorSharma, C.en_US
dc.contributor.authorKaur, Ghuman N.en_US
dc.contributor.authorKathuria, P.en_US
dc.contributor.authorBohra, D.en_US
dc.date.accessioned2024-09-24T06:58:00Z
dc.date.available2024-09-24T06:58:00Z
dc.date.issued2024-04
dc.description.abstractBackground: Premature rupture of the membranes (PROM) complicates 3% of pregnancies and its associated with adverse perinatal outcome. Methods: This was a case control study conducted over a period of two years. Our aim was to evaluate the bacterial colonization of genital tract of antenatal patients who presented with preterm premature rupture of membranes and their maternal and neonatal complications. We studied 6023 patients during our study period among which 156 patients presented with preterm premature rupture of membranes. Results: PPROM was found more commonly among age 25-30 years (46.79%) with p<0.001. Out of 156 pregnant women with PPROM, only 16 patients (10.26%) developed clinical chorioamnionitis. We observed that 43.59% patients (n=68) with PPROM underwent LSCS which was significantly higher than control group (19.93%). Among them 81.41% (n=127) of the patients delivered within 24 hours of admission. Among 156 patients, 94 (59.12%) mothers had babies with birth weight ranging between 1.5-2.5 kg as compared to control group where 30.51% mothers had low birth weight babies. The difference was statistically significant. Approximately 18.24% babies developed respiratory distress syndrome requiring ICU care in study group as compared to 3.03% in control group and the difference was statistically significant. Conclusions: It is important to diagnose the PPROM early and manage the patient until delivery for better outcome. Timely intervention after proper analysis of risk and benefit of early termination helps in reducing adverse perinatal outcomes, reduced NICU admissions and unnecessary interventions for neonates.en_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, All India Institute of Medical Sciences Jodhpur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, All India Institute of Medical Sciences Jodhpur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, All India Institute of Medical Sciences Jodhpur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, All India Institute of Medical Sciences Jodhpur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, All India Institute of Medical Sciences Jodhpur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, All India Institute of Medical Sciences Jodhpur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, All India Institute of Medical Sciences Jodhpur, Rajasthan, Indiaen_US
dc.identifier.citationJhirwal M., Singh P., Shekhar S., Sharma C., Kaur Ghuman N., Kathuria P., Bohra D.. High diversity in the vaginal microbiome in women following preterm premature rupture of membranes and its effect on fetomaternal outcome. International Journal of Community Medicine and Public Health. 2024 Apr; 11(4): 1612-1617en_US
dc.identifier.issn2394-6032
dc.identifier.issn2394-6040
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/227950
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.18203/2394-6040.ijcmph20240899en_US
dc.subjectChorioamnionitisen_US
dc.subjectNeonatal sepsisen_US
dc.subjectPreterm premature rupture of membranesen_US
dc.subjectRespiratory distress syndromeen_US
dc.titleHigh diversity in the vaginal microbiome in women following preterm premature rupture of membranes and its effect on fetomaternal outcomeen_US
dc.typeJournal Articleen_US
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