In-Vivo Study on Anxiolytic Effects of Hydroalcoholic Extract of Agaricus blazei Murill

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dc.contributor.authorAli, Mehwish Muraden_US
dc.contributor.authorBaig, Mirza Tasaweren_US
dc.contributor.authorAslam, Muhammeden_US
dc.contributor.authorIbrahim, Sadafen_US
dc.contributor.authorJabeen, Aishaen_US
dc.contributor.authorShaikh, Sabaen_US
dc.contributor.authorMirza, Ahmed Shahiden_US
dc.contributor.authorFatima, Rasheedaen_US
dc.contributor.authorShahid, Uzmaen_US
dc.contributor.authorSyed, Nayelen_US
dc.contributor.authorRawat, Arvaen_US
dc.date.accessioned2020-09-24T07:52:49Z
dc.date.available2020-09-24T07:52:49Z
dc.date.issued2019-08
dc.description.abstractBackground: Anxiety involved panic attacks either having or not having social fear, social anxiety disorder, generalized anxiety disorder as well as separation anxiety disorder is known to be marked mental diseases. It is related to high medical cost and a significant load of disease. Agaricus blazei Murill (AbM) is a mushroom and possesses immunemodulating and antimicrobial effects both in-vivo and in-vitro and as well as it has been used to treat cancer, hepatitis, dermatitis, and hyperlipidemia traditionally. Method: In this experiment evaluation of anxiolytic effect of AbM on mice has been done by using Elevated Plus Maze test, open field test and motor co-ordination test by rotarod. Mice (Mus musculus) weighing 22-25 grams, were divided into 4 groups (n=6). Oral administration of hydro-alcoholic extract of AbM was utilized in 2 doses i.e. 136.5 mg/kg and 273 mg/kg. Group, I received vehicle (distilled water 10 ml/kg), p.o. Group II received standard (diazepam 1 mg/kg), i.p. Group III and IV orally received hydro-alcoholic extract of AbM (136.5 mg/kg and 273 mg/kg, respectively). Result: In Elevated Plus Maze test, oral administration of hydro-alcoholic extract of AbM (136.5 mg/kg and 273 mg/kg, respectively) exhibited significant (p<0.01) elevation in the percentage of number of open arm entries (48.0 ± 1.1% and 48.93 ± 2.1% respectively) and time spent in open arm (14.92 ± 1.9% and 84.17 ± 2.4%). Conclusion: Hence it is concluded that hydro-alcoholic extract of AbM can be a new therapeutic agent to treat anxiety.en_US
dc.identifier.affiliationsFaculty of Pharmacy, Ziauddin University, Karachi, Pakistanen_US
dc.identifier.affiliationsFaculty of Pharmacy, Sindh University, Jamshoro Pakistanen_US
dc.identifier.affiliationsDepartment of Medicine, Ziauddin University, Karachi, Pakistanen_US
dc.identifier.citationAli Mehwish Murad, Baig Mirza Tasawer, Aslam Muhammed, Ibrahim Sadaf, Jabeen Aisha, Shaikh Saba, Mirza Ahmed Shahid, Fatima Rasheeda, Shahid Uzma, Syed Nayel, Rawat Arva. In-Vivo Study on Anxiolytic Effects of Hydroalcoholic Extract of Agaricus blazei Murill. International Journal of Medical Research & Health Sciences. 2019 Aug; 8(8): 70-74en_US
dc.identifier.issn2319-5886
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/205096
dc.languageenen_US
dc.publisherSumathi Publicationsen_US
dc.relation.issuenumber8en_US
dc.relation.volume8en_US
dc.source.urihttps://www.ijmrhs.com/abstract/invivo-study-on-anxiolytic-effects-of-hydroalcoholic-extract-of-agaricus-blazei-murill-18760.htmlen_US
dc.subjectAnxietyen_US
dc.subjectAgaricus blazei Murillen_US
dc.subjectOpen field testen_US
dc.subjectElevated plus maze-testen_US
dc.subjectMotor co-ordination test by rotaroden_US
dc.titleIn-Vivo Study on Anxiolytic Effects of Hydroalcoholic Extract of Agaricus blazei Murillen_US
dc.typeJournal Articleen_US
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