Clinico-microbiological study of neonatal sepsis.
Loading...
Date
2015-04
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Neonatal sepsis, a systemic infection manifesting in the first month of life is a leading cause of
mortality in the newborn .Blood culture is the main stay in the diagnosis of neonatal sepsis. The
present study focuses on the bacterial agents, the antibiogram and the clinical risk factors associated
with neonatal sepsis. One hundred and ten neonates with clinical suspicion of neonatal sepsis were
included in this study. Bacterial pathogens isolated in positive blood cultures were identified and
the antibiotic susceptibility testing was performed. The risk factors were noted from the case records
& statistical analysis was done using the Chi square test. Thirty six (32.72%) cultures were positive
among 110 suspected cases of neonatal sepsis. 22(61.11%) cases presented with early onset sepsis
and 14(38.89%) presented as late onset sepsis. The common bacteria isolated were Klebsiella spp.,
Escherichia coli & Staphylococcus aureus. Antibiotics effective against gram negative bacilli were
cefaperazone/sulbactam and piperacillin/tazobactam. The rate of Methicillin resistant
Staphylococcus aureus isolation was 57%. Gram negative bacilli predominate as agents of neonatal
sepsis & antibiotic resistance among bacteria is on rise. Thus there is a need for continuous
screening and surveillance for antibiotic resistance in NICU.
Description
Keywords
Neonatal sepsis, Risk factors, Antibiotic resistance, Early onset sepsis
Citation
Agarwal Avinika, Bhat Sevitha. Clinico-microbiological study of neonatal sepsis. Journal of International Medicine and Dentistry. 2015 Apr; 2(1): 22-29.