Formulation of fast disintegrating domperidone tablets using Plantago ovata mucilage by 32 full factorial design.

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dc.contributor.authorShahidulla, S M
dc.contributor.authorKhan, Mohib
dc.contributor.authorJayaveera, K N
dc.date.accessioned2015-12-14T04:19:59Z
dc.date.available2015-12-14T04:19:59Z
dc.date.issued2015
dc.description.abstractThe present work was carried out to study the disintegrant property of plantago ovata mucilage. The objective of the work was to formulate Fast disintegrating tablets of Domperidon with a view to enhance patient compliances and dissolution rate by direct compression method using 3² full factorial design. Plantago ovata mucilage (2-10% w/w) was used as natural superdisintegrant and microcrystalline cellulose (0-30% w/w) was used as diluent, along with directly compressible mannitol to enhance mouth feel. The tablets were evaluated for hardness, friability, thickness, drug content uniformity, in vitro dispersion time, wetting time and water absorption ratio. Based on in vitro dispersion time (approximately 10s); the formulation containing 10% w/w Plantago ovata mucilage and 30%w/w microcrystalline cellulose was found to be promising and tested for in vitro drug release pattern (in 0.1 N HCl), short-term stability (at 40º/75% RH for 3 month) and drug-excipient interaction. Surface response plots are presented to graphically represent the effect of independent variables (concentrations of Plantago ovata mucilage and microcrystalline cellulose) on the in vitro dispersion time. The validity of the generated mathematical model was tested by preparing two extra-design check point formula-tions. The optimized tablet formulation was compared with conventional commercial tablet formulation for drug release profiles. This formulation showed nearly four-fold faster drug release (t50% 2.85 min) compared to the conventional commercial tablet formulation (t50% 7.85 min). Short-term stability studies on the formulation indicated that there are no significant changes in drug content and in vitro dispersion time (p < 0.05).en_US
dc.identifier.citationShahidulla S M, Khan Mohib, Jayaveera K N. Formulation of fast disintegrating domperidone tablets using Plantago ovata mucilage by 32 full factorial design. International Current Pharmaceutical Journal. 2015; 4(8): 415-419.en_US
dc.identifier.issn2224-9486
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/168002
dc.language.isoenen_US
dc.source.urihttps://www.banglajol.info/index.php/ICPJ/article/view/24023en_US
dc.subjectDomperidonen_US
dc.subjectfast disintegrating tabletsen_US
dc.subjectPlantago ovata mucilageen_US
dc.subjectmicrocrystalline celluloseen_US
dc.subject3² full factorial designen_US
dc.titleFormulation of fast disintegrating domperidone tablets using Plantago ovata mucilage by 32 full factorial design.en_US
dc.typeArticleen_US
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