Anti-inflammatory activity of theophylline on carrageenan-induced paw edema in male wistar rats.
dc.contributor.author | Srinivasa, K | |
dc.contributor.author | Chandrasekhar, B V S | |
dc.contributor.author | Srinivasa, J | |
dc.date.accessioned | 2014-12-16T05:32:43Z | |
dc.date.available | 2014-12-16T05:32:43Z | |
dc.date.issued | 2013-05 | |
dc.description.abstract | Background: Evaluate the anti-inflammatory property of theophylline on rat hind paw edema using carrageenan-induced acute inflammatory model. Methods: Wistar male rats (150-200 gm) were divided into 7 groups- 3 standard groups, 3 test groups and 1 control group. Each group consists of six rats. A control group was treated with 0.2ml of normal saline, 3 standard groups were treated with different doses of Diclofenac (Standard drug): 5 mg/kg, 10 mg/kg, 15 mg/kg body weight, respectively and 3 test groups were treated with different doses of Theophylline (Test drug): 5 mg/kg , 10 mg/kg and 15 mg/kg, respectively. The anti-inflammatory property was assessed by plethysmograph. Results: Theophylline demonstrated a significant anti-inflammatory property at different dose levels when compared to controls (p > 0.05). However this anti-inflammatory activity was less as compared to standard drug. Conclusions: Theophylline exhibited a dose dependent anti-inflammatory activity in a carrageenan model of inflammation. | en_US |
dc.identifier.citation | Srinivasa K, Chandrasekhar B V S, Srinivasa J. Anti-inflammatory activity of theophylline on carrageenan-induced paw edema in male wistar rats. International Journal of Basic & Clinical Pharmacology. 2013 May-Jun; 2(3): 298-301. | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/153867 | |
dc.language.iso | en | en_US |
dc.source.uri | https://www.ijbcp.com/?mno=33171 | en_US |
dc.subject | Theophylline, | en_US |
dc.subject | Carrageenan | en_US |
dc.subject | Anti-inflammatory activity | en_US |
dc.title | Anti-inflammatory activity of theophylline on carrageenan-induced paw edema in male wistar rats. | en_US |
dc.type | Article | en_US |
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