Anti-inflammatory activity of theophylline on carrageenan-induced paw edema in male wistar rats.

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dc.contributor.authorSrinivasa, K
dc.contributor.authorChandrasekhar, B V S
dc.contributor.authorSrinivasa, J
dc.date.accessioned2014-12-16T05:32:43Z
dc.date.available2014-12-16T05:32:43Z
dc.date.issued2013-05
dc.description.abstractBackground: Evaluate the anti-inflammatory property of theophylline on rat hind paw edema using carrageenan-induced acute inflammatory model. Methods: Wistar male rats (150-200 gm) were divided into 7 groups- 3 standard groups, 3 test groups and 1 control group. Each group consists of six rats. A control group was treated with 0.2ml of normal saline, 3 standard groups were treated with different doses of Diclofenac (Standard drug): 5 mg/kg, 10 mg/kg, 15 mg/kg body weight, respectively and 3 test groups were treated with different doses of Theophylline (Test drug): 5 mg/kg , 10 mg/kg and 15 mg/kg, respectively. The anti-inflammatory property was assessed by plethysmograph. Results: Theophylline demonstrated a significant anti-inflammatory property at different dose levels when compared to controls (p > 0.05). However this anti-inflammatory activity was less as compared to standard drug. Conclusions: Theophylline exhibited a dose dependent anti-inflammatory activity in a carrageenan model of inflammation.en_US
dc.identifier.citationSrinivasa K, Chandrasekhar B V S, Srinivasa J. Anti-inflammatory activity of theophylline on carrageenan-induced paw edema in male wistar rats. International Journal of Basic & Clinical Pharmacology. 2013 May-Jun; 2(3): 298-301.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/153867
dc.language.isoenen_US
dc.source.urihttps://www.ijbcp.com/?mno=33171en_US
dc.subjectTheophylline,en_US
dc.subjectCarrageenanen_US
dc.subjectAnti-inflammatory activityen_US
dc.titleAnti-inflammatory activity of theophylline on carrageenan-induced paw edema in male wistar rats.en_US
dc.typeArticleen_US
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