Isolation, partial purification and pharmacodynamics of a slow contractile substance in the venom sac extract of the wasp Vespa cincta Fabr.

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dc.contributor.authorSarangi, Ben_US
dc.contributor.authorKar, P Ken_US
dc.contributor.authorDatta, Aen_US
dc.contributor.authorGomes, Aen_US
dc.contributor.authorLahiri, S Cen_US
dc.date.accessioned2009-05-28T12:37:44Z
dc.date.available2009-05-28T12:37:44Z
dc.date.issued1990-06-01en_US
dc.description.abstractThe venom of V. cincta contains acetylcholine (ACh), histamine and 5-hydroxytryptamine (5-HT). Blockers of these agonists did not block completely the hypotensive and smooth muscle contractile activity of venom. On smooth muscle, there was a residual slow contraction. The active substance which produced this slow contraction was separated by solvent extraction, gel filtration and TLC. The purified material (which has been provisionally designated "Vecikinin") lowered cat, rat and guinea pig blood pressure, increased amplitude of cardiac contraction, and increased capillary permeability. Vecikinin contracted several smooth muscle preparations (rat uterus, rat ascending colon, guinea pig ileum, guinea pig colon and rat ileum), while relaxing rat duodenum. Its contractile activity was not lost on boiling, but acid or alkali-boiling reduced its contractile activity. It was inactivated on incubation with chymotrypsin and carboxypeptidase but not with trypsin, pepsin or leucine aminopeptidase. It is a peptide, appears to be of low molecular weight, and could be distinguished from substance P, angiotensin, bradykinin and hornet or wasp kinin.en_US
dc.description.affiliationDepartment of Pharmacology, School of Tropical Medicine, Calcutta, India.en_US
dc.identifier.citationSarangi B, Kar PK, Datta A, Gomes A, Lahiri SC. Isolation, partial purification and pharmacodynamics of a slow contractile substance in the venom sac extract of the wasp Vespa cincta Fabr. Indian Journal of Experimental Biology. 1990 Jun; 28(6): 557-61en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58339
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBee Venoms --pharmacologyen_US
dc.subject.meshBlood Pressureen_US
dc.subject.meshCapillary Permeabilityen_US
dc.subject.meshCatsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshMuscle Contractionen_US
dc.subject.meshMuscle, Smooth --physiologyen_US
dc.subject.meshMyocardial Contractionen_US
dc.subject.meshRatsen_US
dc.subject.meshWasp Venoms --isolation & purificationen_US
dc.titleIsolation, partial purification and pharmacodynamics of a slow contractile substance in the venom sac extract of the wasp Vespa cincta Fabr.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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