Aflatoxin B1 induced hepatocarcinogenesis in neonatal rats.

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dc.contributor.authorMathur, Men_US
dc.contributor.authorRizvi, T Aen_US
dc.contributor.authorNayak, N Cen_US
dc.date.accessioned2009-05-28T13:05:08Z
dc.date.available2009-05-28T13:05:08Z
dc.date.issued1992-03-01en_US
dc.description.abstractRole of cell replication on aflatoxin B1 (AFB1) induced hepatocarcinogenesis was investigated in neonatal rats showing persistence of cell replication in the liver for 21 days of post natal life. Adult (8-10 weeks old) rats displaying no hepatocytic proliferation served as controls. Three doses of AFB1 were administered to both the groups at intervals of 48 hr with the doses starting on 10th day of age in the neonatal group. Appearance of phenotypically altered preneoplastic hepatocytes was quantitated in both the groups. A significantly higher incidence of preneoplastic foci was recorded in neonatal rats as compared to adult animals. The results suggest that presence of cell replication in neonatal rats at the time of AFB1 administration enhances the process of hepatocarcinogenesis.en_US
dc.description.affiliationDepartment of Pathology, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationMathur M, Rizvi TA, Nayak NC. Aflatoxin B1 induced hepatocarcinogenesis in neonatal rats. Indian Journal of Experimental Biology. 1992 Mar; 30(3): 165-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58943
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAflatoxin B1 --adverse effectsen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshCell Division --drug effectsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshLiver --pathologyen_US
dc.subject.meshLiver Neoplasms, Experimental --chemically induceden_US
dc.subject.meshLongitudinal Studiesen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.titleAflatoxin B1 induced hepatocarcinogenesis in neonatal rats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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