Dietary protein deficiency induced changes in protein kinase C activity and phospholipid metabolism in rat hepatocytes.

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dc.contributor.authorKathayat, Ren_US
dc.contributor.authorJaiswal, A Sen_US
dc.contributor.authorBasir, S Fen_US
dc.contributor.authorBansal, S Ken_US
dc.date.accessioned2009-05-28T15:11:47Z
dc.date.available2009-05-28T15:11:47Z
dc.date.issued1997-09-25en_US
dc.description.abstractDietary protein deficiency is known to alter the protein kinase C activity in various tissues of rats. Protein kinase C activity is influenced by the metabolism of membrane phosphoinositides and phosphatidyl choline (PC). For metabolic studies, hepatocytes have been the cells of choice of various workers. Therefore, studies on protein kinase C and these phospholipids were conducted in hepatocytes of rats maintained on three different diets viz. casein (20% protein) deficient (4% protein, rice flour as source of protein) and supplemented (deficient diet supplemented with L-lysine and DL-threonine) diet for 28 days. The protein deficiency in diet led to a decline in protein kinase C activity (P < 0.01) without effecting its translocation, an increase in phosphatidyl inositol 4,5-bisphosphate (P < 0.001) and a decrease in phosphatidyl inositol 4-monophosphate and phosphatidyl inositol (P < 0.01) but did not alter the PC contents, as compared to the casein group. Supplementation of deficient diet with L-lysine and DL-threonine could considerably reverse the effect of deficiency of protein in diet. The results suggest that quality of dietary protein is mainly relevant for maintaining phospholipid metabolism and physiology of hepatocytes and thus the signalling mechanism in these cells.en_US
dc.description.affiliationDepartment of Biochemistry, V.P. Chest Institute, University of Delhi, India.en_US
dc.identifier.citationKathayat R, Jaiswal AS, Basir SF, Bansal SK. Dietary protein deficiency induced changes in protein kinase C activity and phospholipid metabolism in rat hepatocytes. Indian Journal of Experimental Biology. 1997 Sep; 35(9): 972-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61677
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshLiver --cytologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPhospholipids --metabolismen_US
dc.subject.meshProtein Deficiencyen_US
dc.subject.meshProtein Kinase C --metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.titleDietary protein deficiency induced changes in protein kinase C activity and phospholipid metabolism in rat hepatocytes.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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