Safety evaluation of chromium picolinate in experimental rats

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dc.contributor.authorV. S., Harish Kumaren_US
dc.contributor.authorBaleed, Sindhura Reddyen_US
dc.contributor.authorA. N., Pradeepen_US
dc.contributor.authorL. J., Kiranen_US
dc.contributor.authorK. G., Shivashankaramurthyen_US
dc.contributor.authorM. S., Raghu Prasadaen_US
dc.date.accessioned2020-04-23T08:00:04Z
dc.date.available2020-04-23T08:00:04Z
dc.date.issued2020-01
dc.description.abstractBackground: Chromium, an essential trace mineral plays an important role in the metabolism of carbohydrate, fat and proteins. Chromium picolinate (Cr.Pic) is used in alternative medicine to treat chromium deficiency. Though Cr.Pic is increasingly used to treat diabetes and obesity, studies on its safety profile is limited.Methods: Acute toxicity study was conducted by oral administration of Cr.Pic (2000 mg/kg body weight). The animals were maintained another 14 days with once a day observation. For sub-chronic studies, test groups were treated with Cr.Pic 10 mg/kg/day for 90 days. Tests for hepatic and renal function were conducted. Effect of Cr.Pic on behavioural changes and motor co-ordination was done on every week. Histopathological studies were conducted on day 90 at the end of the experiment.Results: Acute toxicity study of Cr.Pic showed no signs of toxicity and mortality. Absence of any behavioural alteration or mortality during the period of 14 days indicates that Cr.Pic has no latent effect. Similar results were obtained with sub-chronic studies suggesting safety of Cr.Pic. Cr.Pic treated groups showed no changes in learning and motor co-ordination compared to the untreated group. No gross histopathological changes were seen in any group indicating safety of Cr.Pic.Conclusions: The present study conferred safety profile of Cr.Pic from normal results obtained in hepatic function, renal function, behavioural and histopathological studies, suggesting its safety.en_US
dc.identifier.affiliationsDepartment of Pharmacology, S S Institute of Medical Sciences and Research Centre, Davangere, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Emergency Medicine, JJMMC, Davangere, Karnataka, Indiaen_US
dc.identifier.citationV. S. Harish Kumar, Baleed Sindhura Reddy, A. N. Pradeep, L. J. Kiran, K. G. Shivashankaramurthy, M. S. Raghu Prasada. Safety evaluation of chromium picolinate in experimental rats. International Journal of Basic & Clinical Pharmacology. 2020 Jan; 9(1): 113-121en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200489
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber1en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20195772en_US
dc.subjectAcute toxicityen_US
dc.subjectChromium picolinateen_US
dc.subjectSub-chronic toxicityen_US
dc.titleSafety evaluation of chromium picolinate in experimental ratsen_US
dc.typeJournal Articleen_US
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