Comparative study of efficacy and safety of pregabalin and gabapentin for treatment of neuropathic pain in oral cavity cancer patients: a comparative, randomized and prospective study

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dc.contributor.authorSaji, S.en_US
dc.contributor.authorSinghal, Y.en_US
dc.contributor.authorPingoliya, S. K.en_US
dc.date.accessioned2024-09-24T06:13:59Z
dc.date.available2024-09-24T06:13:59Z
dc.date.issued2024-08
dc.description.abstractBackground: Pain in patients with oral cancers can limit the normal functioning and quality of life. Neuropathic pain raises the anxiety and depression levels, increases the morbidity and decreases the efficiency to work. Neuropathic pain is frequently diagnosed as a complication of cancer pain due to direct invasion of nerves, plexus or compression, and side effect of chemotherapy, radiation injury or surgery. Methods: A total of 60 patients were divided randomly into two groups based on treatment: group P (pregabalin) and group G (gabapentin). The intensity of pain was measured using visual analog scale (VAS) and DN4 questionnaire (Douleur Neuropathique 4) was used to evaluate neuropathic component. Changes in pain score and neuropathic component was assessed at 2nd and 4th week of follow up. Data was collected and analysed using SPSS 20.0 software at level of significance being p<0.05. Results: At baseline, the mean±SD of VAS score in group P was 7.20±0.79; in group G was 7.13±0.66. At 2nd week, the mean±SD of VAS score in group P was 4.5±0.91; in group G was 4.46±0.88. At 4th week, the mean±SD of VAS score in group P was 3.66±0.69; in group G was 3.83±0.85. At baseline, the mean±SD of DN4 score in group P was 7.13±0.80; in group G was 6.93±0.85. At 2nd week, the mean±SD of DN4 score in group P was 4.73±0.92; in group G was 4.46±0.82. At 4th week, the mean±SD of DN4 score in group P was 3.73±0.42; in group G was 3.93±0.62. Conclusions: Pregabalin was found to be more effective with lesser side effects than gabapentinen_US
dc.identifier.affiliationsDepartment of Palliative Medicine, SMS Medical College Jaipur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Palliative Medicine, SMS Medical College Jaipur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Palliative Medicine, SMS Medical College Jaipur, Rajasthan, Indiaen_US
dc.identifier.citationSaji S., Singhal Y., Pingoliya S. K.. Comparative study of efficacy and safety of pregabalin and gabapentin for treatment of neuropathic pain in oral cavity cancer patients: a comparative, randomized and prospective study. International Journal of Basic & Clinical Pharmacology. 2024 Jul; 13(4): 493-497en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/226764
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume13en_US
dc.source.urihttps://doi.org/10.18203/2319-2003.ijbcp20241648en_US
dc.subjectGabapentinen_US
dc.subjectOral canceren_US
dc.subjectPainen_US
dc.subjectPalliative careen_US
dc.subjectPregabalinen_US
dc.titleComparative study of efficacy and safety of pregabalin and gabapentin for treatment of neuropathic pain in oral cavity cancer patients: a comparative, randomized and prospective studyen_US
dc.typeJournal Articleen_US
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