Characterization of Solid Binary Systems of Efavirenz and Hydroxypropyl-β-Cyclodextrin

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dc.contributor.authorArali, Bharatien_US
dc.contributor.authorY, Anand Kumaren_US
dc.contributor.authorC, Mallikarjuna Settyen_US
dc.date.accessioned2020-09-24T07:34:32Z
dc.date.available2020-09-24T07:34:32Z
dc.date.issued2019-02
dc.description.abstractEfavirenz is a widely prescribed anti-retroviral drug that belongs to BCS class II and exhibit low and variable oral bioavailability due to its poor aqueous solubility and it requires enhancement in solubility and dissolution rate for increasing its oral bioavailability. The aim of this study was to increase the solubility of Efavirenz (EFA) by complexing it with Hydroxypropyl-β-cyclodextrin (HPβCD). Solid binary systems were prepared by co-grinding and microwave irradiation methods. The interaction of EFA with HPβCD was evaluated by Phase solubility studies, in vitro dissolution studies and different analytical techniques including Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). The apparent stability constant revealed EFA with HPβCD produces 1:1 M stoichiometric complex. The host guest interactions studied by FTIR and DSC confirmed true inclusion of EFA with HPβCD at 1:2 M. The Dissolution rates of EFA- HPβCD binary systems were faster when compared to physical mixture and pure drug. Overall the rank order of improvement in dissolution properties of Efavirenz with ratios is 1:2M > 1:1M and methods MW > CG > PM > Pure drug. One-way ANOVA suggest the DP60 and DE60 values were significantly higher (P<0.05) in solid binary systems prepared by microwave irradiation method when compared to co-grinding and its corresponding physical mixtures and pure drug.en_US
dc.identifier.affiliationsDepartment of Pharmaceutics, East West College of Pharmacy, Bengaluru, Indiaen_US
dc.identifier.citationArali Bharati, Y Anand Kumar, C Mallikarjuna Setty. Characterization of Solid Binary Systems of Efavirenz and Hydroxypropyl-β-Cyclodextrin. International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL). 2019 Feb; 8(1): 15-20en_US
dc.identifier.issn2280-0238
dc.identifier.issn2393-932X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203832
dc.languageenen_US
dc.publisherSociety for research and Development in Educationen_US
dc.relation.issuenumber1en_US
dc.relation.volume8en_US
dc.source.urihttps://doi.org/10.21276/IJRDPL.2278-0238.2019.8(1).15-20en_US
dc.subjectEfavirenzen_US
dc.subjectHydroxypropyl-?-cyclodextrinen_US
dc.subjectsolid binary systemsen_US
dc.subjectSolubilityen_US
dc.subjectDissolutionen_US
dc.titleCharacterization of Solid Binary Systems of Efavirenz and Hydroxypropyl-β-Cyclodextrinen_US
dc.typeJournal Articleen_US
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