Solubility enhancement of poorly water soluble drug by using nano-suspension technology.
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Date
2013-10
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Abstract
Solubility is an essential factor for drug effectiveness, independent of the route of administration. Poorly soluble drugs are often a challenging task for
formulators in the industry. Conventional approaches for enhancement of solubility have limited applicability, especially when the drugs are poorly soluble
simultaneously in aqueous and in non-aqueous media. Nanosuspension technology can be used to improve the stability as well as the bioavailability of poorly
soluble drugs. The problem is even more complex for drugs like itraconazole, simvastatin, and carbamazepine which are poorly soluble in both aqueous and
nonaqueous media, belonging to BCS class II as classified by biopharmaceutical classification system. Formulation as nanosuspension is an attractive and promising
alternative to solve these problems. Nanosuspension consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion. Preparation
of nanosuspension is simple and applicable to all drugs which are water insoluble. A nanosuspension not only solves the problems of poor solubility and
bioavailability, but also alters the pharmacokinetics of drug and thus improves drug safety and efficacy. This review article describes the preparation methods,
characterization, and applications of the nanosuspension.
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Keywords
Bioavailability, colloidal dispersion, solubility enhancement, nanosuspension
Citation
Soumya Mishra, Gupta Saurabh, Jain Rahul, Mazumder R. Solubility enhancement of poorly water soluble drug by using nano-suspension technology. International Journal of Research and Development in Pharmacy and Life Sciences. 2013 Oct-Nov; 2(6): 642-649.