Effect of combined treatment of thioperamide with some antiepileptic drugs on methionine-sulfoximine induced convulsions in mice.

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dc.contributor.authorVohora, Divya
dc.contributor.authorKhanam, Razia
dc.contributor.authorPal, Shanthi N
dc.contributor.authorPillai, K K
dc.date.accessioned2013-02-12T05:01:13Z
dc.date.available2013-02-12T05:01:13Z
dc.date.issued2010-08
dc.description.abstractMethionine-sulfoximine (MSO), a convulsant is known to increase the activity of histamine N-methyl transferase. The effect of a selective H3 receptor agonist R- ( ) methylhistamine (RAMH) and antagonist (thioperamide, THP) and some antiepileptic drugs (gabapentin and sodium valproate) have been evaluated on MSO-induced convulsions in mice. The effect of THP was also evaluated in combination with these antiepileptic drugs. Sodium valproate (300 mg/kg, po) and gabapentin (400 mg/kg, po) offered protection against MSO-induced convulsions as evidenced by a significant prolongation of latency to abnormal dorsoflexion and complete protection against mortality within 6 h of administration. THP (15 mg/kg, ip) alone and in combination with sub-effective doses of gabapentin (75 mg/kg, po) and sodium valproate (75 mg/kg, po) revealed no significant differences from the control group or either drug alone. Hence, the convulsant action of MSO does not appear to be mediated via histaminergic mechanisms.en_US
dc.identifier.citationVohora Divya, Khanam Razia, Pal Shanthi N, Pillai K K. Effect of combined treatment of thioperamide with some antiepileptic drugs on methionine-sulfoximine induced convulsions in mice. Indian Journal of Experimental Biology. 2010 Aug; 48(8): 858-860.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/145041
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/9993en_US
dc.subjectGabapentinen_US
dc.subjectMethionine-sulfoximineen_US
dc.subjectSodium valproateen_US
dc.subjectThioperamideen_US
dc.titleEffect of combined treatment of thioperamide with some antiepileptic drugs on methionine-sulfoximine induced convulsions in mice.en_US
dc.typeArticleen_US
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