ACUTE TOXICITY STUDY OF ARSENICUM ALBUM IN WISTAR ALBINO RATS

Simple item page
dc.contributor.authorA, Men_US
dc.contributor.authorS, Ben_US
dc.contributor.authorS, Ven_US
dc.contributor.authorAT, SVen_US
dc.contributor.authorMS, Uen_US
dc.contributor.authorA, Ven_US
dc.contributor.authorTM, K.en_US
dc.date.accessioned2025-05-12T07:20:50Z
dc.date.available2025-05-12T07:20:50Z
dc.date.issued2024-12
dc.description.abstractObjective: In India, homeopathic medicines derived from arsenic trioxide, such as Arsenicum album (A. album), are used to treat COVID-19. Many of the Arsenicum album's adverse events during the COVID treatment led to drug discontinuation. Nonetheless, Ayurvedic, Yoga and Naturopathy, Unani, Siddha, and Homoeopathic (AYUSH) medicine prescribes it. Researching Arsenicum album's toxicity is now essential since it will help decide whether or not the drug can be utilized during treatment. Methods: Acute oral toxicity was performed in Wistar Albino Rats to find out the effects of Arsenicum album in various organs. Rats were divided into three groups: Group A (control), Group B (Arsenicum album 1000?l/100g) and Group C (2000?l/100g). A Single bolus dose of Arsenicum album was given orally and the study period was conducted for 14 d. The rats were subsequently sacrificed on the 15th d and biochemical and histopathological studies were done. Results: The acute oral toxicity study showed median Lethal dose (LD50) was greater than 2000?l/100g for Arsenicum album. Biochemical analysis showed a significant increase in HDL level in Group C (2000?l/100g) compared to Group A (control) and Group B (1000?l/100g). [P<0.05]. Blood glucose, when compared to Group A (control) is increased in both groups B and C but statistically not significant (p>0.05). When compared to Group A (control) there is no significant change in blood urea level in Groups B and C (p>0.05). Serum creatinine is increased in Groups B and C compared to Group A (control) but statistically not significant (p>0.05). LDL cholesterol is increased in groups B and C compared to Group A (control) but statistically not significant (p>0.05). Macroscopic examination of the organs of Group B and C revealed no abnormalities when compared with the organs of Group A (control). Histopathological analysis showed mild hepatocellular and renal toxicity in Groups B and C with extensive hemorrhages and periportal lymphocytic infiltrates.en_US
dc.identifier.affiliationsKMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsKMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsSwamy Vivekanandha Medical College and Hospital, Thiruchengode, Namakkal, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsKMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsKMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsKaruna Medical College, Palakkad, Kerala, Indiaen_US
dc.identifier.affiliationsKMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, Indiaen_US
dc.identifier.citationA M, S B, S V, AT SV, MS U, A V, TM K.. ACUTE TOXICITY STUDY OF ARSENICUM ALBUM IN WISTAR ALBINO RATS . International Journal of Pharmacy and Pharmaceutical Sciences . 2024 Dec; 16(12): 37-41en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246455
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber12en_US
dc.relation.volume16en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2024v16i12.52513en_US
dc.subjectArsenicum albumen_US
dc.subjectAcute toxicityen_US
dc.subjectCoviden_US
dc.subjectHerbal medicineen_US
dc.titleACUTE TOXICITY STUDY OF ARSENICUM ALBUM IN WISTAR ALBINO RATSen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ijpps2024v16n12p37.pdf
Size:
1.03 MB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Pharmacy and Pharmaceutical Sciences