Neuroprotective and Anti-inflammatory Effects of Terminalia superba Engler & Diels (Combretaceae): A Potential Therapeutic Approach for Cerebral Malaria

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dc.contributor.authorRolland, KGen_US
dc.contributor.authorDieudonné, SKen_US
dc.contributor.authorAbou, Ben_US
dc.contributor.authorJoseph, DA.en_US
dc.date.accessioned2025-05-12T10:23:17Z
dc.date.available2025-05-12T10:23:17Z
dc.date.issued2024-12
dc.description.abstractCerebral malaria is one of the most severe complications of malaria, primarily caused by Plasmodium falciparum. The search for alternative or complementary treatments to classical antimalarial therapies is crucial in light of the emergence of drug resistance. Terminalia superba, a tropical medicinal plant, has traditionally been used to treat various diseases, including those with parasitic etiology. This study aims to evaluate the potential of Terminalia superba in managing cerebral malaria. Ethanolic extracts of T. superba were obtained by maceration of the bark of the plant in 70% alcohol. Cytotoxicity and neuroprotection tests were conducted on neurons (SH-SY5Y-neurons) using the MTT method. The activity against neuroinflammation was assessed through the LPS (Lipopolysaccharide) test, measuring cytokines TNF-?, Interleukin 8, Interleukin 6, and Interleukin 1?. The ethanolic extract of Terminalia superba exhibited non-toxic activity on neurons with an IC50 greater than 200 µg/mL. This extract protected astrocytes against oxidative stress induced by H2O2 (500 µM). Cell survival increased from 35% to 45%, 59%, 61%, and 73% at concentrations of 3.125, 12.5, 50, and 200 µg/mL, respectively. Terminalia superba also reduced the overproduction of cytokines by LPS-stimulated neurons, demonstrating its efficacy against neuroinflammation. The ethanolic extract of Terminalia superba, in addition to being non-cytotoxic, possesses antioxidant and anti-inflammatory properties on neurons. These properties could play an important role in the management of cerebral malaria. Further studies should lead to the development of a drug against cerebral malaria based on the bark of T. superba.en_US
dc.identifier.affiliationsLaboratory of Biology and Health, UFR Biosciences, Félix Houphouët-Boigny University, 01 BPV 34 Abidjan 01, Abidjan, Côte d'Ivoireen_US
dc.identifier.affiliationsLaboratory of Biology and Health, UFR Biosciences, Félix Houphouët-Boigny University, 01 BPV 34 Abidjan 01, Abidjan, Côte d'Ivoire and Swiss Center for Scientific Research in Côte d’Ivoire, Abidjan 01 BP 1303, Côte d’Ivoireen_US
dc.identifier.affiliationsLaboratory of Biology and Health, UFR Biosciences, Félix Houphouët-Boigny University, 01 BPV 34 Abidjan 01, Abidjan, Côte d'Ivoireen_US
dc.identifier.affiliationsLaboratory of Biology and Health, UFR Biosciences, Félix Houphouët-Boigny University, 01 BPV 34 Abidjan 01, Abidjan, Côte d'Ivoire and Department of Biochemistry, Pasteur Institute of Côte d’Ivoire, Abidjan Cocody CHU, Côte d’Ivoire.en_US
dc.identifier.citationRolland KG, Dieudonné SK, Abou B, Joseph DA.. Neuroprotective and Anti-inflammatory Effects of Terminalia superba Engler & Diels (Combretaceae): A Potential Therapeutic Approach for Cerebral Malaria . Journal of Pharmaceutical Research International. 2024 Dec; 36(12): 206-212en_US
dc.identifier.issn2456-9119
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247685
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber12en_US
dc.relation.volume36en_US
dc.source.urihttps://doi.org/10.9734/jpri/2024/v36i127640en_US
dc.subjectAstrocytesen_US
dc.subjectcerebral malariaen_US
dc.subjectcytokinesen_US
dc.subjectplasmodium falciparumen_US
dc.subjectterminalia superbaen_US
dc.titleNeuroprotective and Anti-inflammatory Effects of Terminalia superba Engler & Diels (Combretaceae): A Potential Therapeutic Approach for Cerebral Malariaen_US
dc.typeJournal Articleen_US
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