Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats.

Simple item page
dc.contributor.authorBalakrishnan, Sen_US
dc.contributor.authorBhargava, V Ken_US
dc.contributor.authorPandhi, Pen_US
dc.date.accessioned2009-05-28T11:32:10Z
dc.date.available2009-05-28T11:32:10Z
dc.date.issued1999-04-21en_US
dc.description.abstractThe activity of nimodipine and nitrendipine against pentylenetetrazole (PTZ) induced seizures in Albino rats was studied alone and in combination with valproate. The median effective dose [ED50] of valproate, nimodipine and nitrendipine were initially determined. All the 3 drugs were injected i.p. 30 min before the induction of seizures. Seizures were induced by PTZ 85 mg/kg i.p., and subsequently the effect of combining ED50 doses of nimodipine and nitrendipine with ED50 dose of valproate was evaluated. ED50 of valproate and nitrendipine were 129 and 2.5 mg/kg respectively. ED50 of nimodipine could not be established since a dose-response relationship was not obtained. Hence, for the purpose of combination studies, 4 mg/kg of nimodipine was used. Both nimodipine (4 mg/kg) and nitrendipine (2.5 mg/kg) decreased the ED50 of valproate from 129 to 40 mg/kg. Both nimodipine and nitrendipine potentiate the activity of valproate against PTZ induced seizures and can be considered as potential adjuvant anticonvulsants which merit further study.en_US
dc.description.affiliationDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.en_US
dc.identifier.citationBalakrishnan S, Bhargava VK, Pandhi P. Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats. Indian Journal of Experimental Biology. 1999 Apr; 37(4): 340-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56850
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnticonvulsants --administration & dosageen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshNimodipine --administration & dosageen_US
dc.subject.meshNitrendipine --administration & dosageen_US
dc.subject.meshPentylenetetrazole --toxicityen_US
dc.subject.meshRatsen_US
dc.subject.meshSeizures --chemically induceden_US
dc.subject.meshValproic Acid --administration & dosageen_US
dc.titleAnticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Experimental Biology