Inhaled theophylline: old drug new tricks?

Simple item page
dc.contributor.authorMalamatari, M.en_US
dc.date.accessioned2024-09-24T06:13:42Z
dc.date.available2024-09-24T06:13:42Z
dc.date.issued2024-02
dc.description.abstractTheophylline and aminophylline (i.e., the soluble complex of theophylline with ethylenediamine) have been used in the treatment of respiratory diseases such as asthma and chronic obstructive pulmonary disease for more than 90 years. Theophylline’s narrow therapeutic index and side effects, as well as the discovery of more potent and safer bronchodilators, made it to fall out of favour with healthcare professionals and patients. New scientific knowledge on the molecular mechanism of action of theophylline, along with increasing clinical evidence suggest that theophylline should be exploited as an anti-inflammatory agent rather than a bronchodilator. This review covers the journey of theophylline from rise to fall and back to its potential re-emergence as a combination formulation with inhaled corticosteroids in the management of chronic inflammatory lung diseases. Several approaches to formulate theophylline either as a monotherapy or as a combination therapy for delivery to the lungs are presented.en_US
dc.identifier.affiliationsDepartment of Pharmacy, Frederick University, Nicosia 1036, Cyprus; Institute for Globally Distributed Open Research and Education (IGDORE), London, UKen_US
dc.identifier.citationMalamatari M.. Inhaled theophylline: old drug new tricks?. International Journal of Basic & Clinical Pharmacology. 2024 Jan; 13(1): 174-180en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/226711
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber1en_US
dc.relation.volume13en_US
dc.source.urihttps://doi.org/10.18203/2319-2003.ijbcp20233912en_US
dc.subjectTheophyllineen_US
dc.subjectRespiratory diseaseen_US
dc.subjectPulmonary drug deliveryen_US
dc.titleInhaled theophylline: old drug new tricks?en_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ijbcp2024v13n1p174.pdf
Size:
489.07 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Basic & Clinical Pharmacology