Evaluation of the Ameliorative Effects of Persea americana Seeds on the Biochemical and Hematological Parameters in Type 2 Diabetic Rats

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dc.contributor.authorMukasa, Y.en_US
dc.date.accessioned2024-11-30T11:33:20Z
dc.date.available2024-11-30T11:33:20Z
dc.date.issued2024-07
dc.description.abstractBackground : Diabetes Mellitus (DM) is a chronic hyperglycemic condition with various types, however, Type 2 DM or Non-Insulin Dependent Diabetes Mellitus (NIDDM) accounts for 90% of all DM cases. Type 2 DM thus poses the biggest burden, necessitating a search for sustainable alternatives to its costly conventional management. Medicinal plant extracts are key to addressing the cost management related challenges, especially for resource limited settings. We studied the effects of Persea americana seed extracts on biochemical and hematological indices because these get deranged in NIDDM, indicative of a worsening prognosis. Studies on seed extracts of P. americana showed beneficial effects in NIDDM, however, these focused majorly on Fasting Blood Glucose (FBG) and lipids. We further explored the effects of the methanolic (ME) and total crude (TCE) extracts on the hematological indices in NIDDM rats. Materials and Methods : Type 2 DM was induced in the study animals using streptozotocin. The diabetic control and glibenclamide (GLB) groups orally received water and 10mg/kg B.W.T of GLB respectively, whereas other groups orally received either 200mg or 400mg doses of both extracts per kg B.W.T. Results : Only the higher dose of the TCE (TCE400) had a comparable FBG lowering effect to GLB (p=0.309), however, all extract groups except ME200 had ameliorative effects (p=0.09, 1.00 and 0.01 for ME400, TCE200 and TCE400 respectively). The effects of all extracts on total cholesterol (TC) and LDL unlike on triglycerides and HDL were significantly (p<0.05) better than glibenclamide’s. Only the TCEs had ameliorative effects on TC levels (p=0.18 and 0.48 for TCE200 and TCE400 respectively). All extracts except ME200, had significantly (p<0.05) better activity on mean MCH and MCV levels in comparison to GLB. Only TCE400 caused a more significant improvement in the mean RBC than GLB (p=0.004) and only TCE400 and ME400 had more significant improvement in Hct levels than GLB (p=0.04). Conclusion: Total crude extracts of Persea americana seed at doses of about 400mg/kg body weight can improve the treatment outcomes of DM in diabetic animals.en_US
dc.identifier.affiliationsPrincipal Investigator, Department of Pharmacology and Therapeutics, Makerere University, P.O Box 4004, Kampala, Ugandaen_US
dc.identifier.citationMukasa Y. . Evaluation of the Ameliorative Effects of Persea americana Seeds on the Biochemical and Hematological Parameters in Type 2 Diabetic Rats. Journal of Clinical and Biomedical Sciences. 2024 Jul; 14(3): 105-114en_US
dc.identifier.issn2319-2453
dc.identifier.issn2231-4180
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/238026
dc.languageenen_US
dc.publisherSri Devaraj Urs Academy of Higher Educationen_US
dc.relation.issuenumber3en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.58739/jcbs/v14i3.109en_US
dc.subjectTraditional medicineen_US
dc.subjectMedicinal planten_US
dc.subjectMacerationen_US
dc.subjectTotal crude extracten_US
dc.subjectDiabetes Mellitusen_US
dc.subjectAmeliorativeen_US
dc.subjectAntidiabeticen_US
dc.subjectOral hypoglycemic agents (OHAs)en_US
dc.titleEvaluation of the Ameliorative Effects of Persea americana Seeds on the Biochemical and Hematological Parameters in Type 2 Diabetic Ratsen_US
dc.typeJournal Articleen_US
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