Thyroid dysfunction modulates glucoregulatory mechanism in rat.

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dc.contributor.authorChakrabarti, Sudiptaen_US
dc.contributor.authorGuria, Srikantaen_US
dc.contributor.authorSamanta, Ipsitaen_US
dc.contributor.authorDas, Madhusudanen_US
dc.date.accessioned2009-05-28T11:19:29Z
dc.date.available2009-05-28T11:19:29Z
dc.date.issued2007-06-26en_US
dc.description.abstractThe role of the thyroid gland in glucose homeostasis remains incompletely understood. To get a better insight hypo-and hyperthyroid conditions were experimentally induced in rat and found severe defects in glucose homeostasis. While blood glucose level returned to normal level after 2.5 hr of oral glucose challenge in control rats the blood glucose level remained high even after 24 hr of glucose load in both hypo- and hyperthyroid rats. These experimentally manipulated rats displayed higher levels of liver glycogen (10.45-22.8-fold) and serum glutamic pyruvic transaminase (1.48-9.8-fold). Liver histology of hyperthyroid treated rats revealed hepatotoxicity. From the results it can be concluded that thyroid gland plays an important role in glucose homeostasis.en_US
dc.description.affiliationDepartment of Zoology, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700 019, India.en_US
dc.identifier.citationChakrabarti S, Guria S, Samanta I, Das M. Thyroid dysfunction modulates glucoregulatory mechanism in rat. Indian Journal of Experimental Biology. 2007 Jun; 45(6): 549-53en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56556
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/5527/1/IJEB%2045%286%29%20549-553.pdfen_US
dc.subject.meshAlanine Transaminase --blooden_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Glucose --analysisen_US
dc.subject.meshBody Weighten_US
dc.subject.meshGlucose --metabolismen_US
dc.subject.meshGlucose Tolerance Testen_US
dc.subject.meshHyperthyroidism --blooden_US
dc.subject.meshHypothyroidism --blooden_US
dc.subject.meshLiver Glycogen --analysisen_US
dc.subject.meshMetabolic Networks and Pathways --physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshThyroid Diseases --blooden_US
dc.subject.meshThyroxine --blooden_US
dc.subject.meshTriiodothyronine --blooden_US
dc.titleThyroid dysfunction modulates glucoregulatory mechanism in rat.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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