Effect of 6-MFA, an interferon inducer obtained from fungus Aspergillus ochraceus on hepatic mixed function oxidase system in rats.

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dc.contributor.authorDhuley, J Nen_US
dc.contributor.authorNaik, S Ren_US
dc.date.accessioned2009-05-28T13:37:27Z
dc.date.available2009-05-28T13:37:27Z
dc.date.issued1996-10-01en_US
dc.description.abstractEffect of 6-MFA (sixth mycelial fraction of acetone), an interferon inducer obtained from fungus A. ochraceus on hepatic mixed function oxidase system (MFO) of rat has been investigated. Treatment with 6-MFA, 100 mg/kg/day, ip for 1-5 days to adult rats inhibited significantly the different indices of MFO system, viz. hepatic cytochrome P-450, cytochrome b5 content, cytochrome c reductase, aminopyrine-N-demethylase and acetanilide hydroxylase activities. Similar treatment for 3 days in young growing rats significantly inhibited MFO system's components except acetanilide hydroxylase activity which showed marked elevation. These effects seem to be specific as in vitro experiments suggested that 6-MFA does not compete with subsdtrates nor it acts as a sponge reacting with the end product to give false inhibitory effect. It is concluded from the present study that 6-MFA like other interferon inducers depresses MFO system in rats. Its possible clinical implications are discussed.en_US
dc.description.affiliationDepartment of Pharmacology & Toxicology, Hindustan Antibiotics Ltd, Pimpri, Pune, India.en_US
dc.identifier.citationDhuley JN, Naik SR. Effect of 6-MFA, an interferon inducer obtained from fungus Aspergillus ochraceus on hepatic mixed function oxidase system in rats. Indian Journal of Experimental Biology. 1996 Oct; 34(10): 1010-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59653
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAspergillus ochraceusen_US
dc.subject.meshEnzyme Inhibitors --toxicityen_US
dc.subject.meshFungal Proteins --isolation & purificationen_US
dc.subject.meshInterferon Inducers --isolation & purificationen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrosomes, Liver --drug effectsen_US
dc.subject.meshMixed Function Oxygenases --antagonists & inhibitorsen_US
dc.subject.meshRatsen_US
dc.titleEffect of 6-MFA, an interferon inducer obtained from fungus Aspergillus ochraceus on hepatic mixed function oxidase system in rats.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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