Assessment of the Phytochemical Composition, Antioxidant Activity, and In-vitro Cytotoxic Effects of Begonia malabarica on Pancreatic Cancer Cell Line

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dc.contributor.authorSakthivadivel, Selvanayahien_US
dc.contributor.authorArumugam, Sabaridasanen_US
dc.contributor.authorMurugan, Muralidharanen_US
dc.contributor.authorRamaiah, Soranamen_US
dc.date.accessioned2024-09-24T08:59:11Z
dc.date.accessioned2024-09-24T11:51:42Z
dc.date.available2024-09-24T08:59:11Z
dc.date.available2024-09-24T11:51:42Z
dc.date.issued2024-02
dc.description.abstractThe study assesses the biological properties of methanolic extracts derived from the leaves, stems, and roots of Begonia malabarica, a native plant species in the mountainous area of southern India. The GC-MS was used to analyze the phytochemicals in the solvent from Begonia malabarica that had been extracted with methanol. The antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and as reference solution is ascorbic acid. The cytotoxicity activity was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) approach. The GC-MS analysis effectively revealed 35 distinctive phytomolecules. The primary constituents, namely tert-butylbenzene (23%), 2-methylnaphthalene (6.2%), ethyl ester of octadecanoic acid (0.9%), and (Z,Z)-9,12-octadecadienoic acid (0.9%), are noted. The results, the methanolic extracts from B. malabarica are antioxidants that have significant levels (P < 0.05) of DPPH radical scavenging activities at different doses. The detected radical scavenging activities exhibited a higher proportion in the stem of B. malabarica. The IC50 values for the methanolic extracts were found to be 0.77 mg/ml, 0.49 mg/ml, and 0.68 mg/ml, respectively. The MTT analysis demonstrated that the methanolic extracts exhibited a considerable increase in cytotoxic activity against the pancreatic cancer (PANC-1) cell line, resulting in a cell viability percentage of 69.63% at a concentration of 31.25µg/ml. These findings confirm the possible biological effects of B. malabarica and its prospective use in different pharmaceutical pursuits in the future.en_US
dc.identifier.affiliationsDepartment of Environmental Sciences, Sri Paramakalyani Centre of Excellence in Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsPG and Research Department of Biotechnology, Sri Vinayaga College of Arts and Science, Ulundurpet, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Environmental Sciences, Sri Paramakalyani Centre of Excellence in Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Environmental Sciences, Sri Paramakalyani Centre of Excellence in Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi, Tamil Nadu, Indiaen_US
dc.identifier.citationSakthivadivel Selvanayahi, Arumugam Sabaridasan, Murugan Muralidharan, Ramaiah Soranam . Assessment of the Phytochemical Composition, Antioxidant Activity, and In-vitro Cytotoxic Effects of Begonia malabarica on Pancreatic Cancer Cell Line . International Journal of Pharmaceutical Sciences and Drug Research . 2024 Jan; 16(1): 119-126en_US
dc.identifier.issn0975–248X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/231602
dc.languageenen_US
dc.publisherMRI Publication Pvt. Ltd.en_US
dc.relation.issuenumber1en_US
dc.relation.volume16en_US
dc.source.urihttps://doi.org/10.25004/IJPSDR.2024.160116en_US
dc.subjectMedicinal planten_US
dc.subjectAntioxidant activityen_US
dc.subjectCytotoxicityen_US
dc.subjectPANC-1 cell lineen_US
dc.titleAssessment of the Phytochemical Composition, Antioxidant Activity, and In-vitro Cytotoxic Effects of Begonia malabarica on Pancreatic Cancer Cell Lineen_US
dc.typeJournal Articleen_US
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