Paediatric Risk of Mortality III Score to Predict Outcome in Patients Admitted to PICU with Dengue Fever

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dc.contributor.authorJain, Akankshaen_US
dc.contributor.authorAlam, Shahzaden_US
dc.contributor.authorShalini, Akunurien_US
dc.contributor.authorMazahir, Rufaidaen_US
dc.date.accessioned2019-11-16T07:23:56Z
dc.date.available2019-11-16T07:23:56Z
dc.date.issued2018-04
dc.description.abstractBackground: The objective of the current study was to evaluate the ability of PRISM III score calculated within 24 hours of PICU admission to predict outcome in patients with dengue fever. Materials & Methods: The prospective cohort study included children admitted to PICU with diagnosis of ‘Dengue with warning sign’ and ‘Severe Dengue’. Outcome included PICU mortality, length of PICU stay (LOS), need for mechanical ventilation and renal replacement therapy (RRT). PRISM III score was calculated and compared with outcome groups. Calibration of the score was measured using Hosmer‑Lemeshow modification of chi square test and discrimination using Area under the curve of Receiver Operating Characteristic curves. Results: This study included 151 patients with 54.3% Dengue with warning signs and 45.7% severe Dengue. Median PRISM III-24 score of patients who died (p-0.001), required RRT (p-0.006), mechanical ventilation (p-0.032) and those with prolonged LOS (p-0.003) were significantly higher. Hosmer‑Lemeshow modification of chi square test to assess calibration showed good fit of PRISM III-24 model to predict mortality (χ2-2.022; p-0.846), need for RRT (χ2-3.564; p-0.614), prolonged LOS (χ2-4.360; p-0.499) and need for mechanical ventilation (χ2-7.497; p-0.186).  ROC curve for the PRISM III-24 model to predict the discriminating power yield an AUC of 0.923 (95% CI: 0.829-1.000) for mortality, 0.953 (95% CI: 0.896-1.000) for need for RRT, 0.682 (95% CI: 0.494-0.870) for need for mechanical ventilation and 0.663 (95% CI: 0.563-0.764) for prolonged LOS. Conclusion: PRISM III is an effective tool to predict mortality and need for RRT in patient with dengue feveren_US
dc.identifier.affiliationsClinical fellow, Birmingham children’s hospital, Birmingham, UK.en_US
dc.identifier.affiliationsAssistant Professor (Pediatric intensive care), Pediatric Cardiac Evaluation and Cardiac Surgery unit, J N Medical College, AMU, Aligarhen_US
dc.identifier.affiliationsClinical Fellow, Noah;s Ark Children Hospital, University hospital of Wales, Cardiff, Wales, UKen_US
dc.identifier.citationJain Akanksha, Alam Shahzad, Shalini Akunuri, Mazahir Rufaida. Paediatric Risk of Mortality III Score to Predict Outcome in Patients Admitted to PICU with Dengue Fever. International Archives of BioMedical and Clinical Research. 2018 Apr-Jun; 4(2): 80-83en_US
dc.identifier.issn2454-9894
dc.identifier.issn2454-9886
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/184137
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber2en_US
dc.relation.volume4en_US
dc.source.urihttps://doi.org/10.21276/iabcr.2018.4.2.24en_US
dc.subjectPediatric Risk Of Mortality Iii Scoreen_US
dc.subjectMortalityen_US
dc.subjectDengue Feveren_US
dc.subjectPediatric Intensive Care Uniten_US
dc.titlePaediatric Risk of Mortality III Score to Predict Outcome in Patients Admitted to PICU with Dengue Feveren_US
dc.typeJournal Articleen_US
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