Association of Angiotensin-I-Converting Enzyme (ACE) Insertion/Deletion Gene Polymorphism with End Stage Renal Disease in Egyptian Patients.

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dc.contributor.authorAbdel-Aziz, A F
dc.contributor.authorEl-Saeed, Afaf
dc.contributor.authorEL-Dahshan, Khaled
dc.contributor.authorEbead, Basma AL-Sayed
dc.date.accessioned2016-03-04T03:16:05Z
dc.date.available2016-03-04T03:16:05Z
dc.date.issued2014-03-11
dc.description.abstractAngiotensin-I-converting enzyme (ACE) insertion/deletion (I/D) polymorphism has been associated with the genetic susceptibility to end stage renal disease (ESRD) in different populations. ACE DD genotype and D allele are associated with ESRD as risk factors in several studies. In this study, we investigated the association between ACE I/D gene polymorphism and ESRD in the Egyptian patients. Frequencies of D allele and DD genotype were significantly increased, while frequencies of I allele and ID genotype were significantly decreased in the ESRD patients when compared with the control subjects (P = .012, OR = 1.82, 95% CI = 1.139-2.915 for DD) and (P = .018, OR = 1.6, 95% CI = 1.082-2.33 for D). In conclusion, ACE DD genotype and D allele are associated with ESRD as risk factors for ESRD in the Egyptian population.en_US
dc.identifier.citationAbdel-Aziz A F, El-Saeed Afaf, El-Dahshan Khaled, Ebead Basma Al-Sayed. Association of Angiotensin-I-Converting Enzyme (ACE) Insertion/Deletion Gene Polymorphism with End Stage Renal Disease in Egyptian Patients. British Journal of Medicine and Medical Research. 2014 Mar; 4(8): 1763-1771.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/175076
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/2935en_US
dc.subjectAngiotensin-I-converting enzyme (I/D) polymorphismen_US
dc.subjectend stage renal diseaseen_US
dc.titleAssociation of Angiotensin-I-Converting Enzyme (ACE) Insertion/Deletion Gene Polymorphism with End Stage Renal Disease in Egyptian Patients.en_US
dc.typeArticleen_US
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