Pathology of ovary, uterus, vagina and gonadotrophs of female mice fed on Zn-deficient diet.

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dc.contributor.authorTaneja, S Ken_US
dc.contributor.authorKaur, Ren_US
dc.date.accessioned2009-05-28T13:50:14Z
dc.date.available2009-05-28T13:50:14Z
dc.date.issued1990-11-01en_US
dc.description.abstractDietary Zn-deficiency in mature female mice for 6 weeks caused a retardation of ovarian growth characterized by lack of vesicular and Grafian follicles, degenerated corpus luteum, distorted cell membranes of granulosa cells with pycnotic nuclei, poor development of theca interna, inordinate accumulation of sudanophilic granules in theca interna and interstitial cells. The vagina and uterus did not exhibit cyclic changes in their cytoarchitecture as a result of the cessation of estrous cycle after 6 weeks of dietary treatment. They displayed wide spread degenerative changes in their myometrial and endometrial layers. The uterine glands appeared collapsed with little or no secretion. The vagina lacked cornification. Their gonadotrophs reacted positive to PAS, identical to the control group observed at diestrous stage. However, they did not display a negative reaction, characteristic of the gonadotrophs at estrous stage of the control group, examined even at an interval of 1 day for 6 days in succession. These results point towards the suspension of steroidogenesis inspite of intact gonadotrophs under Zn-deficiency condition.en_US
dc.description.affiliationDepartment of Zoology, Panjab University, Chandigarh, India.en_US
dc.identifier.citationTaneja SK, Kaur R. Pathology of ovary, uterus, vagina and gonadotrophs of female mice fed on Zn-deficient diet. Indian Journal of Experimental Biology. 1990 Nov; 28(11): 1058-65en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59928
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGonadotropins, Pituitary --metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshOvary --metabolismen_US
dc.subject.meshSteroids --biosynthesisen_US
dc.subject.meshUterus --metabolismen_US
dc.subject.meshVagina --metabolismen_US
dc.subject.meshZinc --deficiencyen_US
dc.titlePathology of ovary, uterus, vagina and gonadotrophs of female mice fed on Zn-deficient diet.en_US
dc.typeJournal Articleen_US
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